Arsenite Induces p70S6K1 Activation and HIF-1alpha Expression in Prostate Cancer Cells

Details

• Personal Author:
  Gao N ; Jiang BH ; Shi X ; Skinner HD ; Zhong XS
• Description:
  Arsenite is ubiquitous in the environment, particularly in the form of contaminated water. Although this metal is a known human carcinogen, its exact mechanism of action remains unclear. P70S6K1 phosphorylates the ribosomal 40S protein leading to increased protein translation, and is an important regulator of cell growth and proliferation. Hypoxia inducible factor-1 (HIF-1) is a basic helix-loop-helix transcription factor composed of two subunits, HIF-1alpha and HIF-1beta. HIF-1 activates the transcription of a number of genes that mediate angiogenesis and tumor formation. In this study we demonstrated that arsenite treatment increased levels of p70S6K1 phosphorylation and p70S6K1 activity in a PI3K and mTOR sensitive manner. We have also shown that arsenite specifically induces HIF-1alpha, but not HIF-1beta, protein levels in prostate cancer cells in a mTOR-dependent manner. [Description provided by NIOSH]
• Subjects:
  Arsenic Carcinogens Inorganic Chemicals Metals Neoplasms Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Arsenic-compounds Arsenites Author Keywords: HIF-1 Cancer Carcinogenesis Carcinogenicity Cell-growth MTOR P70S6K1 PI3K Prostate-cancer Tumorigenesis Tumorigens Tumors

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  19-23
• Volume:
  255
• Issue:
  1
• NIOSHTIC Number:
  nn:20025984
• Citation:
  Mol Cell Biochem 2004 Jan; 255(1-2):19-23
• Email:
  bhjiang@hsc.wvu.edu
• CAS Registry Number:
  Arsenite (CAS RN 15502-74-6)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:03efc76318d3f981e0eae9f8e607d0b7c855ec42dae368cb06bf30a36608cf8b9735ba4d32975996bc71f052224a195188c1be284099996bc06ba713d5594fa6
• Download URL:
  https://stacks.cdc.gov/view/cdc/197135/cdc_197135_DS1.pdf
• File Type:
  [PDF - 131.43 KB ]