Molecular Mechanisms of Arsenic Carcinogenesis

Details

• Personal Author:
  Costa M ; Huang C ; Ke Q ; Shi X
• Description:
  Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways. [Description provided by NIOSH]
• Subjects:
  Arsenic Carcinogens Genetics Inorganic Chemicals Metals Neoplasms Occupational Health Safety
• Keywords:
  Arsenic-compounds Author Keywords: Arsenic Cancer Cancer-rates Carcinogenesis Carcinogenicity Exposure-levels Gene Expression Genes Genetic Toxicity Genotoxic-effects Kinase Metalloids Methylation Reactive Oxygen Species Signal Transduction

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  57-66
• Volume:
  255
• Issue:
  1
• NIOSHTIC Number:
  nn:20025983
• Citation:
  Mol Cell Biochem 2004 Jan; 255(1-2):57-66
• Contact Point Address:
  C. Huang, Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
• Email:
  chuanshu@env.med.nyu.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:011516baf83a9f5c41e5074edbdad8f9db3208ba064ea44954c6c418ec95e746435172e2fb8b803b822c17eba8efd2adc94dadcfb2d8ba62fc0a67761012c9fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/197134/cdc_197134_DS1.pdf
• File Type:
  [PDF - 76.95 KB ]