Late-Phase Airway Response to Trimellitic Anhydride in Brown Norway Rat: Effect of Dexamethasone and Salbutamol

Details

• Personal Author:
  Kreiss, Kathleen ; McCanlies E ; Schuler C ; Weston A
• Description:
  Genetic research among beryllium-exposed workers has shown that the HLA-DPB1Glu69 polymorphism is associated with both beryllium sensitization and chronic beryllium disease. Workers who obtain personal genetic information in the context of this genetic research may be at risk for employment and insurance discrimination. NIOSH is concerned about the potential risks faced by beryllium workers who obtain their personal genetic information and has made educating workers about their risks and benefits a priority. Precautions taken to protect workers participating in NIOSH research include a CDC assurance of confidentiality that the individuals' genetic results can only be used for beryllium-related research; a consent form indicating that personal genetic results can only be obtained by the individual; informational meetings; and a two-step process for obtaining results. Since 1998 1,182 current and former workers have participated in our research; 73 (6.2%) have taken the first step to request their results, and 32 (2.7%) have completed the process and actually obtained their results. While the need to protect worker participants' genetic results must remain paramount, genetic research holds promise for understanding the molecular mechanisms of sensitization and CBD, for developing animal models, exposure standards to protect all workers, and better treatments and interventions. [Description provided by NIOSH]
• Subjects:
  Animals Beryllium Genetics Hypersensitivity Occupational Diseases Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Animal-studies Beryllium-compounds Beryllium-disease Diseases Genetic-factors Models Occupational-diseases Occupational-exposure Risk-analysis Risk-factors Sensitization Workers

  More +
• Publisher:
  American Public Health Association
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20030125
• Citation:
  APHA 132nd Annual Meeting and Exposition, Washington, DC, November 6-10, 2004. Washington, DC: American Public Health Association, 2004 Nov; :81844
• Contact Point Address:
  Erin McCanlies, PhD, HELD/BEB, National Institute for Occupational Safety and Health, 1095 Willowdale, Morgantown, WV 26505, 304-285-6132
• Email:
  EIM4@cdc.gov
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  False
• Source Full Name:
  APHA 132nd Annual Meeting of the American Public Health Association, November 6-10, 2004
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:94944fdb3c6b15de079442de80da71323ecc33b3ee5a66558cc6179ae0578eb446610613cf20fb1bd7936b850a3fb0b6cbe94e06afc39fe781a158e02897cb49
• Download URL:
  https://stacks.cdc.gov/view/cdc/190946/cdc_190946_DS1.pdf
• File Type:
  [PDF - 94.00 KB ]