HLA-DPB1 and Chronic Beryllium Disease: A HuGE Review

Details

• Personal Author:
  Andrew M ; Kreiss, Kathleen ; McCanlies EC ; Weston A
• Description:
  The human leukocyte antigen (HLA) complex is a series of genes located on chromosome 6 that are important in normal immune function. Susceptibility to chronic beryllium disease, a granulomatous lung disease that appears in workers exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers implicated a glutamic acid residue at position 69 (HLA-DPB1(Glu69)) in chronic beryllium disease. This finding has since been extended to specific HLA-DPB1(Glu69) alleles. Specific job tasks have also been implicated in degree of risk, and in this paper the authors explore gene-environment interaction. The utility of this genetic information for prospective, current, and former beryllium workers must be weighed against the potential for employment and insurance discrimination. Continued research in the beryllium-exposed population will be important for improving personal risk assessment and identifying high-risk genes associated with disease progression. [Description provided by NIOSH]
• Subjects:
  Beryllium Epidemiology Genetics Lung Diseases Metals, Heavy Occupational Exposure Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Berylliosis Beryllium Beryllium-compounds Beryllium-disease Chronic Beryllium Disease Exposure-levels Genes Genetic-factors Genetic Screening Heavy-metals HLA-DP Antigens HLADPB1 Lung-disease Occupational-exposure Occupational-health Occupational Exposure Workers

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• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  388-398
• Volume:
  157
• Issue:
  5
• NIOSHTIC Number:
  nn:20022661
• Citation:
  Am J Epidemiol 2003 Mar; 157(5):388-398
• Contact Point Address:
  Dr. Erin C. McCaniles, National Institute for Occupational Safety and Health, MS-L4020, 1095 Willowdale Road, Morgantown, WV 26505-2888
• Email:
  eim4@cdc.gov
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Research Tools and Approaches: Risk Assessment Methods ; Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fe5b3d4e077e269f24801c62b83b019b309a430ccccd08bad3178c7e58a74cd9f9e19a258ff7a64500ea34c11fe9e09b6f592e35ebb64c44fb015c47b7a2e30f
• Download URL:
  https://stacks.cdc.gov/view/cdc/199357/cdc_199357_DS1.pdf
• File Type:
  [PDF - 162.44 KB ]