Beryllium-Stimulated Release of Tumor Necrosis Factor-Alpha, Interleukin-6, and Their Soluble Receptors in Chronic Beryllium Disease

Details

• Personal Author:
  Newman, Lee S. ; Tinkle SS
• Description:
  Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnterleukin-6 (IL-6), and their soluble receptors, soluble TNF receptor I (sTNF RI), sTNF RII, and sIL-6R and that chronic exposure to antigen would increase production of soluble receptors in the serum and BAL fluid (BALF) of beryllium-sensitized and CBD patients. We have demonstrated (1) similar constitutive TNF-alpha, IL-6, and soluble receptor production by control subjects and CBD patients, (2) a BeSO4-stimulated increase in TNF-alpha and IL-6 production by CBD-derived BAL cells, and (3) a BeSO4-induced decrease in sTNF RII production by BAL cells from control subjects. We measured increased serum sTNF RI and serum and BALF sIL-6R in beryllium-sensitized subjects and increased sTNF RI and RII in serum and sIL-6R and sTNF RII and BALF in CBD patients. These changes correlated with pulmonary lymphocytosis and clinical measures of disease severity, indicating that soluble receptors may reflect disease status. [Description provided by NIOSH]
• Subjects:
  Beryllium Immune System Lung Diseases Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Beryllium-compounds Beryllium-disease Exposure-levels Immune-reaction Lung-disease Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 3 ; OSHA Region 8 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  156
• Issue:
  6
• NIOSHTIC Number:
  nn:20025297
• Citation:
  Am J Respir Crit Care Med 1997 Dec; 156(6):1884-1891
• Contact Point Address:
  Sally S. Tinkle, Ph.D., National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Road, Morgantown, WV 26505
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:665e9e1303ea35359533e4bc2b3f506d59c0552087c74c8f48b2053ac7b55d38528f5563c807d01fa61ab725d416dc96775224c8ed657d8db48823cf766ee90b
• Download URL:
  https://stacks.cdc.gov/view/cdc/196734/cdc_196734_DS1.pdf
• File Type:
  [PDF - 87.85 KB ]