Beryllium-Stimulated Release of Tumor Necrosis Factor-Alpha, Interleukin-6, and Their Soluble Receptors in Chronic Beryllium Disease

Details

• Personal Author:
  Newman, Lee S. ; Tinkle SS
• Description:
  Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnterleukin-6 (IL-6), and their soluble receptors, soluble TNF receptor I (sTNF RI), sTNF RII, and sIL-6R and that chronic exposure to antigen would increase production of soluble receptors in the serum and BAL fluid (BALF) of beryllium-sensitized and CBD patients. We have demonstrated (1) similar constitutive TNF-alpha, IL-6, and soluble receptor production by control subjects and CBD patients, (2) a BeSO4-stimulated increase in TNF-alpha and IL-6 production by CBD-derived BAL cells, and (3) a BeSO4-induced decrease in sTNF RII production by BAL cells from control subjects. We measured increased serum sTNF RI and serum and BALF sIL-6R in beryllium-sensitized subjects and increased sTNF RI and RII in serum and sIL-6R and sTNF RII and BALF in CBD patients. These changes correlated with pulmonary lymphocytosis and clinical measures of disease severity, indicating that soluble receptors may reflect disease status. Description provided by NIOSH
• Subjects:
  • Beryllium
  • Immune System
  • Lung Diseases
  • Occupational Health
  • Respiratory Tract Diseases
  • Safety
• Keywords:
  • Beryllium-compounds
  • Beryllium-disease
  • Immune-reaction
  • Lung-disease
  • Exposure-levels
  • Pulmonary-system-disorders
  • Respiratory-system-disorders
• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 3 ; OSHA Region 8 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  156
• Issue:
  6
• NIOSHTIC Number:
  nn:20025297
• Citation:
  Am J Respir Crit Care Med 1997 Dec; 156(6):1884-1891
• Contact Point Address:
  Sally S. Tinkle, Ph.D., National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Road, Morgantown, WV 26505
• CAS Registry Number:
  • Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Download URL:
  https://stacks.cdc.gov/view/cdc/196734/cdc_196734_DS1.pdf
• File Type:
  [PDF - 87.85 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:665e9e1303ea35359533e4bc2b3f506d59c0552087c74c8f48b2053ac7b55d38528f5563c807d01fa61ab725d416dc96775224c8ed657d8db48823cf766ee90b