Persistent Specific Airway Responsiveness in Rats Sensitized to and Challenged with Trimellitic Anhyrdride (TMA)

Details

• Personal Author:
  Lewis, Daniel M. ; Siegel, Paul D. ; Zhang X
• Description:
  TMA is an organic acid anhydride that is widely used in industry. It can induce specific IgE and cause occupational asthma in sensitized individuals. Persistent occupational asthma, even with antigen/hapten avoidance can be seen is approximately 20% of the cases. Duration of both circulating TMA-specific IgE and specific airway responsiveness was studied in a TMA sensitized Brown Norway rat asthma model as possible contributory factors to persistent asthma. TMA powder (4 mg) was applied to 4 anesthetized rats' backs (clipped with scissors) on days 0, 7, 14 and 21 and washed off after 4 hrs. Specific IgE analyses and airway challenge with TMA (40 mg/m 3 for 10 min) were performed on day 35 and day 386. The ELISA OD values for TMA-specific IgE were 0.46 +/- 0.07 and 0.12 +/- 0.02 on day 35 and day 386, respectively (non-specific binding from control sera OD=0.08 +/- 0.002). Dual, early- (EAR) and late-phase (LAR) airway responses (indicated by enhanced pause, an index of airway resistance) were observed on day 35. A dual response was noted upon rechallenge on day 386 in 3 rats and LAR-only in the 4th rat. These results demonstrate the persistence of specific airway responsive-ness to TMA, even though circulating specific-IgE had drastically declined. [Description provided by NIOSH]
• Subjects:
  Animals Asthma Asthma, Occupational Laboratories Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Airway-obstruction Airway-resistance Animal-studies Bronchial-asthma Laboratory-animals Models Organic-acids Pulmonary-system-disorders Respiratory-system-disorders
• ISSN:
  1096-6080
• Publisher:
  Society of Toxicology
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  48
• Volume:
  78
• NIOSHTIC Number:
  nn:20025045
• Citation:
  Toxicologist 2004 Mar; 78(S-1):48
• CAS Registry Number:
  Trimellitic anhydride (CAS RN 552-30-7)
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 43nd Annual Meeting and ToxExpo, March 21-25, 2004, Baltimore, Maryland
• Supplement:
  S-1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2aeea26b72de262f11e3f574ad5e1e58f76e02fdbf04a2cb5d2056fb00a0bfff53871d2e0b12d9623564014cf0398fd27b6e0c76cc9e28c76ea9301da13fafad
• Download URL:
  https://stacks.cdc.gov/view/cdc/196555/cdc_196555_DS1.pdf
• File Type:
  [PDF - 82.76 KB ]