Roles of Epidemiology, Pathology, Molecular Biology, and Biomarkers in the Investigation of Occupational Lung Cancer

Details

• Personal Author:
  Ducatman B ; Green F ; Schulte P ; Vallyathan V
• Description:
  The pathology and molecular biology of lung cancer demonstrate that these tumors evolve through a series of mutations, molecular changes, and corresponding morphologic changes. To elucidate how occupational and environmental factors influence lung cancer histogenesis it is important not only to understand epidemiology and the interactions between etiologic agents but also to integrate information from pathology, biochemistry and molecular biology. This review focuses on the range of techniques currently available for characterizing lung cancer and how their prudent use can be beneficial in the identification of occupational carcinogens. Because many occupational and environmental lung cancers are caused by multiple etiologic agents, the integration of histology with cellular, biochemical and molecular biomarker techniques may provide new approaches for understanding the disease process. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Neoplasms Occupational Health Pathology Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Histomorphology Lung-cancer Lung-disease Lung-disorders Molecular-biology Molecular-structure Morphology Pulmonary-system-disorders Respiratory-system-disorders Tumors
• ISSN:
  1093-7404
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  91-116
• Volume:
  1
• Issue:
  2
• NIOSHTIC Number:
  nn:20025041
• Citation:
  J Toxicol Environ Health B 1998 Apr-Jun; 1(2):91-116
• Contact Point Address:
  Dr. Val Vallyathan, Pathology and Physiology Research Branch, HELD, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:36972c8b27a066518a103e9fda538aab5b53b3913443da8c52bc54c4d10707fa8f8e8d55ed5d0abbf073fd9911b8a2bcbb18bbdd9dfcd4960ad1fa6d3b86efc0
• Download URL:
  https://stacks.cdc.gov/view/cdc/196552/cdc_196552_DS1.pdf
• File Type:
  [PDF - 1.62 MB ]