Lung Cancer-Associated JmjC Domain Protein Mdig Suppresses Formation of Tri-Methyl Lysine 9 of Histone H3

Details

• Personal Author:
  Beezhold K ; Castranova, Vincent ; Chang Q ; Chen F ; Lu Y ; Rojanasakul Y ; Shi X ; Zhang Y ; Zhao H
• Description:
  Lung cancer is the most common cancer worldwide, accounting for 1.3 million cancer deaths annually. Despite extensive studies over the past decade, the detailed mechanism about the initiation and development of the lung cancer is still elusive. In the present report, we showed that overexpression of mdig is a common feature of the non-small cell lung cancer. Gene silencing or overexpression of mdig revealed that mdig is involved in demethylation of tri-methyl lysine 9 on histone H3, leading to an increase in ribosomal RNA expression. The transcriptional regulation of ribosomal RNA gene by mdig is achieved through abrogating tri-methyl lysine 9 on histone H3 and enhancing RNA polymerase I occupancy in the promoter region of the ribosomal RNA gene as demonstrated by chromatin immunoprecipitation. The pronounced expression of mdig in lung cancer tissues but not normal lung tissues, thus, suggests that mdig possesses oncogenic property through antagonizing tri-methyl lysine 9 on histone H3 and promoting ribosomal RNA synthesis. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Mdig Gene Cancer H3K9me3 Histone Demethylation Lung-cancer Lung-disease Lung-disorders Lung Cancer Mineral Dust Pulmonary-cancer Pulmonary-system-disorders Respiratory-neoplasms Respiratory-system-disorders

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• ISSN:
  1538-4101
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  13
• NIOSHTIC Number:
  nn:20035649
• Citation:
  Cell Cycle 2009 Jul; 8(13):2101-2109
• Contact Point Address:
  Fei Chen, NIOSH/PPRB, 1095 Willowdale Road, Morgantown, WV 26505 USA
• Email:
  lfd3@cdc.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  Cell Cycle
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16cdf3f39c8f07ed0a900d84d59d95101a84fc006a59ab066ccbb3095178a864d420e9f6c01ab96f1550d0398ac69b7ddc6d46a41723237e2c2abda69ed66e77
• Download URL:
  https://stacks.cdc.gov/view/cdc/187443/cdc_187443_DS1.pdf
• File Type:
  [PDF - 1.53 MB ]