CYP17 Genotype and Breast Cancer Risk

Details

• Personal Author:
  Bleiweiss IJ ; Ksieski HB ; Maloney N ; Pan C-F ; Roy N ; Weston A ; Wolff MS
• Description:
  The MspAI polymorphism in the 5' untranslated region of CYP17 has been evaluated as a breast cancer risk factor in a hospital-based case-control study in New York City. The study population consisted of 363 women [123 breast cancer patients and 240 patient controls (123 benign breast disease without atypical hyperplasia, 117 women without breast disease)]. There were 224 Caucasians (76 cases, 148 controls), 55 African-Americans (20 cases, 35 controls) and 84 Hispanics (27 cases, 57 controls); 142 premenopausal women and 221 postmenopausal women. Consistent with a previous report (Feigelson et al., Cancer Res., 57: 1063-1065, 1997) we found no evidence to implicate the minor variant (restriction site present allele, designated A2) as a breast cancer risk factor. Furthermore, we sought evidence to implicate the minor variant of CYP17 in the development of more aggressive breast cancers (n = 38/121) as had been reported previously. Although confidence intervals (CI) overlap, the data presented here do not provide support for previously reported findings (odds ratio, 0.9; 95% CI, 0.4-2.0; n = 38 versus odds ratio, 2.5; 95% CI, 1.1-5.2; n = 40). Clearly this question needs to be resolved in a larger study. No evidence was found to support the contention that inheritance of the minor variant is a predictor of early age at menarche. Allelic frequencies between different ethnic groups were not found to be different with the exception of Hispanic controls, in which the genotypic distribution was not consistent with the Hardy-Weinberg equilibrium. [Description provided by NIOSH]
• Subjects:
  Demography Mutagens Neoplasms Occupational Health Race Factors Safety Women
• Keywords:
  Breast-cancer Cancer Cancer-rates Demographic-characteristics Gene-mutation Mutagenicity Racial-factors Statistical-analysis
• ISSN:
  1055-9965
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  10
• NIOSHTIC Number:
  nn:20024904
• Citation:
  Cancer Epidemiol Biomark Prev 1998 Oct; 7(10):941-944
• Contact Point Address:
  NIOSH-CDC, MS 3014, HELD-TMBB, 1095 Willowdale Road, Morgantown WV 26505-2888
• Email:
  agw8@cdc.gov
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:14d958618b5ca49fb77ec7eac68fb767f837b8c9260dcaa11c13286dc64cf95962cfa2cda708f44ef5fcd7e44f7cbf61e79b33693004de145ad6e7a7cf1ef45c
• Download URL:
  https://stacks.cdc.gov/view/cdc/196486/cdc_196486_DS1.pdf
• File Type:
  [PDF - 713.53 KB ]