Lack of association between HER2(V655) and breast cancer in a US population.

Details

• Personal Author:
  Keshava C ; McCanlies EC ; Weston A ; Wolff MS
• Description:
  A recent study in a population of Chinese women revealed an association between inheritance of a moderately common polymorphism (0.10-0.15) of HER2 (I655V) and excess risk of breast cancer (OR = 12.7, 95% CI = 1.6-99.5) (Xie et al., J. Natl. Cancer Inst., 92:412-417, 2000). Also, a stronger relationship was claimed in younger women (adjusted OR = 1.7, 95% CI = 1.1-2.6). We tested this hypothesis in a population of US women enrolled in a hospital based case control study in New York City (n = 137 cases and 291 controls, matched 1:2 on age and self-reported race/ethnicity). No evidence was found to support an association between inheritance of the 655-valine variant of HER2 and excess breast cancer risk. Our population consisted of African-Americans (n = 34 cases/58 controls), Caucasians (n = 77/162) and Latinas (26/71). Genotypic distributions for all groups were consistent with Hardy-Weinburg population laws (all p-valves fell within the range 0.16-0.91). Interestingly, HER2V655 allelic frequencies were found to vary with race (African-Americans 0.05, Caucasians 0.16, Latinas 0.15), differences between African-Americans and Caucasians and African-Americans and Latinas were significant (p-values = 0.002 and 0.001, respectively). No association was found between inheritance of HER2V655 and breast cancer, either in the group as a whole (carriers OR = 1.2, 0.8-1.9 or homozygotes OR = 1.2, 0.4-4.2) or when considered by racial groups or when limited to younger women (<54 years:carriers OR = 1.4, 0.7-2.6 or homozygotes OR = 3.1, 0.7-14.3). [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Demography Epidemiology Genetics Neoplasms Occupational Health Race Factors Safety Women
• Keywords:
  Epidemiology; Statistical-analysis; Cancer; Breast-cancer; Humans; Women; Genetic-factors; Age-factors; Age-groups; Racial-factors; Demographic-characteristics
• ISSN:
  0002-9297
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  67
• Issue:
  4
• NIOSHTIC Number:
  nn:20032332
• Citation:
  Am J Hum Genet 2000 Oct; 67(4)(Suppl 2):105
• Contact Point Address:
  Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Human Genetics
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248010/cdc_248010_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]