Recovery from 6 Weeks of Repeated Strain Injury to Rat Soleus Muscles

Details

• Personal Author:
  Miller, G. Roger ; Smith CA ; Stauber FD ; Stauber WT
• Description:
  Recovery from chronic strain injury (50 strains daily, five times weekly for 6 weeks to hyperactive soleus muscles) was followed for 3 months in female rats after cessation of chronic hyperactivity induced by pretreatment of the plantar flexor muscles with tetanus toxin. After 6 weeks of repeated strains, muscle mass decreased by 62%, myofiber areas were reduced by 87%, and noncontractile tissue expanded dramatically by 222%. Collagen content increased by almost ninefold (control 40 +/- 3 microg/mg, chronic injury 392 +/- 53 microg/mg), whereas the molar ratio of collagen (pyridinoline) crosslinks to collagen remained the same (control 0.20 +/- 0.01, chronic injury 0.16 +/- 0.01). After 3 months of ambulation, muscle mass returned to normal but myofiber areas remained smaller by 21%, noncontractile tissue was still markedly elevated by 18% with increased collagen content (107 +/- 15 microg/mg), and the molar ratio of crosslinks to collagen increased by 75% during recovery. Thus, rat soleus muscles recovered very slowly and incompletely from chronic strain injuries that produced muscle fibrosis, highlighting the necessity of devising preventative strategies for repeated strain injuries. [Description provided by NIOSH]
• Subjects:
  Animals Fibrosis Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Collagen High-performance Liquid Chromatography (HPLC) Injuries Laboratory Animals Morphometry Muscle Muscle Stress Muscle Tension Musculoskeletal System Disorders Pyridinoline Skeletal Disorders Skeletal System Disorders

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• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  23
• Issue:
  12
• NIOSHTIC Number:
  nn:20024482
• Citation:
  Muscle Nerve 2000 Dec; 23(12):1819-1825
• Contact Point Address:
  W.T. Stauber, Department of Physiology, West Virginia University, PO Box 9229, Morgantown, WV 26506, USA
• Email:
  wstauber@hsc.wvu.edu
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19920101
• Source Full Name:
  Muscle & Nerve
• End Date:
  20050531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61294c8ddb8d0f83b4e4852dfdbfd521d5f35b57af9cea749ce38322e85f3bd488df60e0554d554b657df8baee07e8b3af3b08d652ae29a25856b104ecb5b66d
• Download URL:
  https://stacks.cdc.gov/view/cdc/196264/cdc_196264_DS1.pdf
• File Type:
  [PDF - 265.47 KB ]