Fibrosis and Intercellular Collagen Connections from Four Weeks of Muscle Strains

Details

• Personal Author:
  Grimmett JG ; Knack KK ; Miller, G. Roger ; Stauber WT
• Description:
  The effect of repeated cycles of muscle strain was studied in the soleus muscle of female rats. Muscle strains were repeated 3X/week for 1 month using two different strain protocols. Striking changes, including marked variability in fiber size, evidence of degradation and regeneration, and an expanded extracellular matrix were pronounced in the fast-stretched muscles but not in the slow-stretched muscles. However, the slow-stretched muscles did contain struts of connective tissue joining adjacent myofibers. Therefore, repeated muscle strains at high strain rates produced morphological changes similar to many myopathies, including fibrosis, whereas adaptation occurred in response to the same number of strains at slow strain rates. Such diverse tissue responses have relevance to the understanding of the mechanisms of skeletal muscle dysfunction in cumulative trauma disorders and in the design of preventive actions and treatments. [Description provided by NIOSH]
• Subjects:
  Animals Cumulative Trauma Disorders Fibrosis Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Skeletal Muscle Collagen Collagen Fibrils Cumulative Trauma Cumulative Trauma Disorders Injury Prevention Laboratory Animals Matrix Morphology Muscle Stress Muscle Tissue Musculoskeletal System Disorders Strains

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• ISSN:
  0148-639X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  423-430
• Volume:
  19
• Issue:
  4
• NIOSHTIC Number:
  nn:20024459
• Citation:
  Muscle Nerve 1996 Apr; 19(4):423-430
• Contact Point Address:
  William T. Stauber, PhD, Department of Physiology, West Virginia University, PO Box 9229, Morgantown, WV 26506-9229
• Federal Fiscal Year:
  1996
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19920101
• Source Full Name:
  Muscle & Nerve
• End Date:
  20050531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f3644e49dd10a6d9c90def9d58c173ad284307ba6503265151d57072efd78d3d7727b71ea978304723f5fe8cc62512d243967c7bb65bab7b26eb8e25aef3e9f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/196255/cdc_196255_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]