Equine Estrogens Induce Apolipoprotein E and Glial Fibrillary Acidic Protein in Mixed Glial Cultures

Details

• Personal Author:
  Anderson CP ; Finch CE ; Hoving S ; O'Callaghan J ; Rozovsky I
• Description:
  Premarin, which contains several equine estrogens, as well as estradiol (E2) as a minor component, is widely used for replacement therapy of estrogen deficits, but little is known of its direct actions on brain cells. In mixed glial cultures, apolipoprotein E (apoE) and glial fibrillary acidic protein (GFAP) are induced by estrogens. GFAP induction showed an inverted-U shape E2 dose response, with a maximum induction at 1 pM, whereas apoE mRNA induction was greatest at 100 pM. GFAP and ApoE mRNAs were induced by equine estrogens in the following order: E2=equilin>estrone>17 alpha-dihydroequilenin. However, the induction of apoE secretion by 17 alpha-dihydroequilenin was as effective as by the other estrogens. The greater response of apoE secretion than GFAP mRNA induction to 17 alpha-dihydroequilenin might be therapeutically important because of the glial scarring during brain lesions, in which GFAP induction has a major role in inhibiting neurite outgrowth, whereas apoE secretion supports neurite outgrowth. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Occupational Health Safety
• Keywords:
  Animal Studies Apolipoprotein E Author Keywords: Equine Estrogens Brain Damage Brain Disorders Glia Glial Fibrillary Acidic Protein In Vitro Studies In Vivo Studies Laboratory Animals Plasticity Premarin Proteins

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• ISSN:
  0304-3940
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  191-194
• Volume:
  323
• Issue:
  3
• NIOSHTIC Number:
  nn:20023524
• Citation:
  Neurosci Lett 2002 May; 323(3):191-194
• Contact Point Address:
  Neurogerontology Division, Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintoch Avenue, Los Angeles, CA 90089-0191, USA
• Email:
  rozovsky@molbio.usc.edu
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Neuroscience Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:35711a43d1a836473995bac4391321bfaf75edf8406cd7e0fa06040255aa7ce550282a0cb6ad9331169d2f7d3d16f326a36ef73948305aa830981280f7671b09
• Download URL:
  https://stacks.cdc.gov/view/cdc/195898/cdc_195898_DS1.pdf
• File Type:
  [PDF - 82.40 KB ]