Long-Term Induction of Fos-Related Antigen-2 After Methamphetamine-, Methylenedioxymethamphetamine-, 1-Methyl-4-Phenyl-1,2, 3,6-Tetrahydropyridine- and Trimethyltin-Induced Brain Injury

Details

• Personal Author:
  Benkovic S ; Gordon MN ; Miller D ; O'Callaghan JP ; Pennypacker KR ; Yang X
• Description:
  A long-term induction of Fos-related antigens has been shown in neurons after brain injury, suggesting that Fos-related antigens are involved in enhancing the transcription of genes related to the process of regeneration and repair. In the present study, we report that levels of Fos-related antigen-2 are elevated in several models of chemically induced brain injury. Trimethyltin, which causes degeneration of neurons primarily in the hippocampus and other limbic regions, results in a five-fold induction of Fos-related antigen-2 immunoreactivity in neurons in the pyramidal and dentate layers of the hippocampus starting at seven days post-treatment and persisting for 60days. Methamphetamine and methylenedioxymethamphetamine, agents which cause degeneration of dopaminergic nerve terminals in the striatum of the mouse, cause an increase in Fos-related antigen-2 immunoreactivity which begins at three days post-treatment and returns to basal levels by days 5 and 15, respectively. Treatment with 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine elevated levels of Fos-related antigen-2 in the mouse striatum at three days post-treatment. This abbreviated time-course of Fos-related antigen-2 induction is consistent with less severe insult (terminal damage) relative to trimethyltin (cell death), but induction occurs during the period of regeneration and repair in both models. Dexfenfluramine, a non-neurotoxic amphetamine, does not induce Fos-related antigen-2 expression. Decreasing core temperature of the mouse, which blocks amphetamine-induced neurotoxicity, also blocks Fos-related antigen-2 induction.In summary, Fos-related antigen-2 is induced in models of both cell death and terminal degeneration, suggesting that this transcription factor may serve as a universal signal transduction molecule involved in the regulation of genes related to regeneration and repair in the CNS. [Description provided by NIOSH]
• Subjects:
  Animals Antigens Laboratories Nervous System Occupational Health Safety
• Keywords:
  Animal Studies AP-1 Author Keywords: Transcription Factor Brain Damage Brain Disorders Central Nervous System Central Nervous System Disorders Gene Regulation Glial Fibrillary Acidic Protein Injuries Laboratory Animals Models Neuronal Regeneration Neurotoxic Effects Neurotoxicity Neurotoxicology Terminal Degeneration Traumatic Injuries

  More +
• ISSN:
  0306-4522
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Florida ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  101
• Issue:
  4
• NIOSHTIC Number:
  nn:20020778
• Citation:
  Neuroscience 2000 Nov; 101(4):913-919
• Email:
  kpennypa@hsc.usf.edu
• CAS Registry Number:
  Trimethylstannane (CAS RN 1631-73-8)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Neuroscience
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:445e167ae55550b25f77931213c0a972b0c65a55c1e2ff4e94f93f716015d67f3081577d31ad67883d4f12716b87ffc79fa9e85306198262299d99364bda3014
• Download URL:
  https://stacks.cdc.gov/view/cdc/198444/cdc_198444_DS1.pdf
• File Type:
  [PDF - 364.17 KB ]