Arsenic-Induced C-Src Activation in Uroepithelium

Details

• Personal Author:
  Hulderman T ; Luster M ; McKinstry M ; Simeonova PP ; Wang S
• Description:
  Environmental or occupational exposure to arsenic is associated with a greatly increased risk of skin, urinary bladder and respiratory tract cancers in arseniasis-endemic areas throughout the world. Arsenic shares many properties of tumor promoters by affecting specific cell signal transduction pathways responsible for cell proliferation. In the current studies, we demonstrate that arsenic activates c-Src in a human uroepithelial cell line. Using pharmacological and genetic inhibition of Src, we found that c-Src activity is a prerequisite for arsenic-induced EGFR and ERK activation in these cells. Consistent with these in vitro observations, exposure of mice to arsenic in drinking water, which has been found previously to be associated with AP-I activation and epithelial proliferation, induces interaction of EGFR and c-Src in the urinary bladder. This response is also accompanied with an increase in ERK activation. The findings represent a potential pathway for mediating arsenic-induced phenotypic changes in the uroepithelium. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Neoplasms Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Skin Skin Diseases
• Keywords:
  Arsenic Compounds Bladder Cancer Cell Damage Environmental Exposure In Vitro Studies Occupational Exposure Respiratory System Disorders Skin Cancer Tumors Urogenital System Disorders
• ISSN:
  0892-6638
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Louisiana ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20023311
• Citation:
  FASEB J 2002 Mar; 16(5):A902
• Contact Point Address:
  NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease ; Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  False
• Source Full Name:
  The FASEB Journal, Experimental Biology 2002, New Orleans, Louisiana, April 20-24, 2002
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:15ce9e7fad32f721a288c7e5f5c31892b4c5f68ee5a908c93c38ead2a313455a0ee15b2ef394eb1969bce06eb66afa25eac50fd34661560171e6742e78970ade
• Download URL:
  https://stacks.cdc.gov/view/cdc/195824/cdc_195824_DS1.pdf
• File Type:
  [PDF - 437.46 KB ]