Dependence of vascular damage on higher frequency components in the rat-tail model

Details

• Personal Author:
  Banerjee RK ; Goenka S ; Kim J ; Peelukhana SV ; Stringer KF
• Description:
  Hand-Arm Vibration Syndrome (HAVS) is caused by hand-transmitted vibration in industrial workers. Current ISO guidelines (ISO 5349) might underestimate vascular injury associated with range of vibration frequencies near resonance. A rat-tail model was used to investigate the effects of higher frequencies >100 Hz on early vascular damage. 13 Male Sprague-Dawley rats (250 +/- 15 gm) were used. Rat-tails were vibrated at 125 Hz and 250 Hz (49 m/s2) for 1D, 5D and 10D; D=days (4 h/day). Structural damage of the ventral artery was quantified by vacuole count using Toluidine blue staining whereas biochemical changes were assessed by nitrotyrosine (NT) staining. The results were analyzed using one-way repeated measures mixed-model ANOVA at p<0.05 level of significance. The structural damage increased at 125 Hz causing significant number of vacuoles (40.62 +/- 9.8) compared to control group (8.36 +/- 2.49) and reduced at 250 Hz (12.33 +/- 2.98) compared to control group (8.36 +/- 2.49). However, the biochemical alterations (NT-signal) increased significantly for 125 Hz (143.35 +/- 5.8 gray scale value, GSV) and for 250 Hz (155.8 +/- 7.35 GSV) compared to the control group (101.7 +/- 4.18 GSV). Our results demonstrate that vascular damage in the form of structural and bio chemical disruption is significant at 125 Hz and 250 Hz. Hence the current ISO guidelines might underestimate vascular damage at frequencies >100 Hz. [Description provided by NIOSH]
• Subjects:
  Animals Biochemistry Biomechanical Phenomena Blood Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety Vibration
• Keywords:
  Analytical-models Animal-studies Author Keywords: Hand-arm Vibration Syndrome Biochemical-indicators Biochemical-tests Biochemical Alterations Biomechanics Blood-vessels Body-regions Hand-injuries Hand-tools Laboratory-animals Laboratory-testing Membrane-dysfunction Musculoskeletal-system-disorders Nitrotyrosine Oxidative-processes Power-tools Resonance Frequency Structural Damage Tissue-culture Tools Vacuoles Vasomotor-system Vibration-effects Vibration-exposure

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• ISSN:
  0019-8366
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  373-385
• Volume:
  51
• Issue:
  4
• NIOSHTIC Number:
  nn:20043672
• Citation:
  Ind Health 2013 Jul; 51(4):373-385
• Contact Point Address:
  Rupak K. Banerjee, School of Dynamic Systems, Mechanical Engineering Program, University of Cincinnati, USA
• Email:
  Rupak.Banerjee@uc.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Industrial Health
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c1703721db5deafab61f048134163d2a95530bbc9b8493f0800f28dd15fbe39f88e976b675a1f8fe46e35f729315a6b2072f7997c463cc871d0e8c5b2b81f548
• Download URL:
  https://stacks.cdc.gov/view/cdc/195508/cdc_195508_DS1.pdf
• File Type:
  [PDF - 417.97 KB ]