Effect of Higher Frequency Components and Duration of Vibration on Bone Tissue Alterations in the Rat-Tail Model

Details

• Journal Article:
  Ind Health
• Personal Author:
  Peelukhana, Srikara V. ; Goenka, Shilpi ; Kim, Brian ; Kim, Jay H. ; Bhattacharya, Amit ; Stringer, Keith F. ; Banerjee, Rupak K.
• Description:
  To formulate more accurate guidelines for musculoskeletal disorders (MSD) linked to Hand-Arm Vibration Syndrome (HAVS), delineation of the response of bone tissue under different frequencies and duration of vibration needs elucidation. Rat-tails were vibrated at 125 Hz (9 rats) and 250 Hz (9 rats), at 49 m/s(2), for 1D (6 rats), 5D (6 rats) and 20D (6 rats); D=days (4 h/d). Rats in the control group (6 rats for the vibration groups; 2 each for 1D, 5D, and 20D) were left in their cages, without being subjected to any vibration. Structural and biochemical damages were quantified using empty lacunae count and nitrotyrosine signal-intensity, respectively. One-way repeated-measure mixed-model ANOVA at p<0.05 level of significance was used for analysis. In the cortical bone, structural damage quantified through empty lacunae count was significant (p<0.05) at 250 Hz (10.82 ± 0.66) in comparison to the control group (7.41 ± 0.76). The biochemical damage was significant (p<0.05) at both the 125 Hz and 250 Hz vibration frequencies. The structural damage was significant (p<0.05) at 5D for cortical bone while the trabecular bone showed significant (p<0.05) damage at 20D time point. Further, the biochemical damage increased with increase in the duration of vibration with a significant (p<0.05) damage observed at 20D time point and a near significant change (p=0.08) observed at 5D time point. Structural and biochemical changes in bone tissue are dependent upon higher vibration frequencies of 125 Hz, 250 Hz and the duration of vibration (5D, 20D).
• Keywords:
  Author Keywords: Hand-arm Vibration Syndrome; Resonance Frequency; Osteocyte; Biochemical Alterations; Nitrotyrosine Biomechanics; Body-regions; Vibration; Vibration-exposure; Vibration-effects; Hand-injuries; Hand-tools; Biochemical-indicators; Biochemical-tests; Analytical-models; Animal-studies; Animals; Laboratory-animals; Laboratory-testing; Musculoskeletal-system-disorders; Blood-vessels; Vasomotor-system; Membrane-dysfunction; Power-tools; Tools; Oxidative-processes; Tissue-culture;
• Source:
  Ind Health. 2015; 53(3):245-259.
• Pubmed ID:
  25843564
• Pubmed Central ID:
  PMC4466877
• Document Type:
  Text
• Funding:
  T42/OH008432-06/OH/NIOSH CDC HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15 pdf pages
• Volume:
  53
• Issue:
  3
• NIOSHTIC Number:
  nn:20047332
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8b589797e019a69194aec63ff7080ad64e9329a5d2e2ddd57116e1f18b6ee76ebae98e84e30079f96ace798fdf9cd6982f1c6aaa813177405ab6dfb40efa7c20
• Download URL:
  https://stacks.cdc.gov/view/cdc/32991/cdc_32991_DS1.pdf
• File Type:
  [PDF - 3.02 MB ]