A Mouse Model for Hand-Arm Vibration Syndrome

Details

• Personal Author:
  Jensen N ; Kommineni C ; Lindsley, William G.
• Description:
  Hand-arm vibration syndrome (HAVS) occurs in workers who use vibrating band tools. Symptoms of HAVS include finger paresthesia and numbness, a loss of manual dexterity and grip strength, and vasospasms in the fingers in response to cold. Although the relationship between vibration exposure and HAVS is well-established, it is not clear how vibration causes tissue damage. The purpose of our research is to identify the fundamental physiological mechanisms involved in the development of HAVS. Toward that end, we have developed a vibration exposure system in which mice are placed in a small cage with a rigid floor that vibrates vertically. The system is capable of exposing mice to sinusoidal vibration at 125 to 1250 Hz with accelerations of up to 49 m/s2 rms. Exposures last for 4 hours/day, 5 days/week, for up to 24 weeks. Initial results indicate that 11 weeks of 125 Hz vibration did not significantly affect the body weights of the mice, and that 12 and 24 weeks of vibration did not significantly affect the liver, kidneys, or stomach. These results suggest that this model can be used to examine the effect of vibration on the mouse foot and lower leg without confounding effects from systemic damage. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety Vibration
• Keywords:
  Animal Studies Arm Injuries Author Keywords: Hand-arm Vibration Syndrome Hand Injuries Laboratory Animals Mice Musculoskeletal Disorders Musculoskeletal System Disorders Occupational Health Vibration Disease Vibration Effects Vibration Exposure

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• ISBN:
  0780376129
• Publisher:
  Biomedical Engineering Society
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; OSHA Region 6 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  448-449
• NIOSHTIC Number:
  nn:20023591
• Citation:
  Proceedings of the Second Joint EMBS/BMES Conference, October 23-26, 2002, Houston, Texas. Landover, MD: Biomedical Engineering Society, 2002 Oct; :448-449
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Peer Reviewed:
  False
• Source Full Name:
  Proceedings of the Second Joint EMBS/BMES Conference, October 23-26, 2002, Houston, Texas
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4acb34b2279cb85839e3ad2cfc6729122c83485b216c645a625e1e677c164236ff254efef13da746448a206cc3be6ebbd2156d2f80a9fa1d90be788946c52f8a
• Download URL:
  https://stacks.cdc.gov/view/cdc/195937/cdc_195937_DS1.pdf
• File Type:
  [PDF - 626.41 KB ]