Reproductive factors and risk of lung cancer in female textile workers in Shanghai, China

Details

• Personal Author:
  Applebaum KM ; Checkoway, Harvey ; Gallagher LG ; Gao DL ; Li W ; Ray RM ; Rosenblatt KA ; Thomas DB
• Description:
  PURPOSE: Hormonal factors may play a role in the development of lung cancer in women. This study examined the relationship between lung cancer and reproductive factors in a large cohort of women, most of whom never smoked (97%). METHODS: A cohort of 267,400 female textile workers in Shanghai, China, enrolled in a trial of breast self-examination provided information on reproductive history, demographical factors, and cigarette smoking at enrollment in 1989-91. The cohort was followed until July of 2000 for incidence of lung cancer; 824 cases were identified. Hazard ratios (HR) and 95% confidence intervals (CI) associated with selected reproductive factors were calculated using Cox proportional hazards modeling, adjusting for smoking, age, and also parity when relevant. RESULTS: Nulliparous women were at increased risk compared to parous women (HR = 1.33, 95% CI 1.00-1.77). Women who had gone through menopause at baseline were at increased risk compared to women of the same age who were still menstruating. Risk was higher in women with a surgical menopause (HR = 1.64, 95% CI 0.96-2.79) than in those with a natural menopause (HR = 1.35, 95% CI 0.84-2.18), and risk was highest in those postmenopausal women with a hysterectomy and bilateral oophorectomy at baseline (HR = 1.39, 95% CI 0.96-2.00), although the risk estimates were not statistically significant. CONCLUSIONS: These results support experimental data that demonstrate a biological role for hormones in lung carcinogenesis. [Description provided by NIOSH]
• Subjects:
  Aging Carcinogens Demography Endocrine System Epidemiology Estrogens Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Textile Industry Urogenital System Women

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• Keywords:
  Age-groups Author Keywords: Parity Cancer Carcinogenesis Cohort Demographic-characteristics Estrogenic-hormones Hormone-activity Hormones Humans Lung-cancer Lung Cancer Physiopathology Reproductive Reproductive-system Risk-analysis Risk-factors Smoking Textile-workers Textiles-industry

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• ISSN:
  0957-5243
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  7
• NIOSHTIC Number:
  nn:20043622
• Citation:
  Cancer Causes Control 2013 Jul; 24(7):1305-1314
• Contact Point Address:
  L. G. Gallagher, Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195, USA
• Email:
  lgallag@u.washington.edu
• Federal Fiscal Year:
  2013
• Performing Organization:
  Boston University Medical Campus
• Peer Reviewed:
  True
• Start Date:
  20080801
• Source Full Name:
  Cancer Causes and Control
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7c21dd58701f7176010d266a3d3253f81790307217dbb0a9d56c7576186a34ae812075cec36f7d27073b8f63733a0d7350c33ce5d630a06633839e70fbd6c56e
• Download URL:
  https://stacks.cdc.gov/view/cdc/195467/cdc_195467_DS1.pdf
• File Type:
  [PDF - 236.93 KB ]