Possible Pro-Carcinogenic Association of Endotoxin on Lung Cancer Among Shanghai Women Textile Workers

Details

• Personal Author:
  Applebaum K ; Astrakianakis G ; Checkoway, Harvey ; Costello S ; Eisen EA ; Gao DL ; Li W ; Lundin JI ; Ray R ; Seixas, Noah S. ; Thomas DB
• Description:
  Background: Endotoxin (lipopolysaccharide) is a widespread contaminant in many environmental settings. Since the 1970s, there has been generally consistent evidence indicating reduced risks for lung cancer associated with occupational endotoxin exposure. Methods: We updated a case-cohort study nested within a cohort of 267 400 female textile workers in Shanghai, China. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989-2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. We applied Cox proportional hazards modelling to estimate exposure-response trends, adjusted for age and smoking, for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of 15 and >15 years since first exposure. Results: We observed no associations between cumulative exposure and lung cancer, irrespective of lag interval. In contrast, analyses by exposure time windows revealed modestly elevated, but not statistically significant relative risks (approximately 1.27) at the highest three exposure quintiles for exposures that occurred >15 years since first exposure. Conclusions: The findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Endotoxins Lipids Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety Textile Industry Women

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• Keywords:
  Author Keywords: Endotoxin Cohort Studies Epidemiology Lipopolysaccharide Lung Cancer Occupational Exposure Occupational Health Textile Industry Textiles Industry Textile Workers
• ISSN:
  0007-0920
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; District of Columbia ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  111
• Issue:
  3
• NIOSHTIC Number:
  nn:20054676
• Citation:
  Br J Cancer 2014 Jul; 111(3):603-607
• Contact Point Address:
  Professor H Checkoway, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA
• Email:
  hcheckoway@ucsd.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  British Journal of Cancer
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4a2518fcb8a85a5d7e960516368452a174e2c6e701b75b7613722b7de9e59c1bf33b2bd07f2d3e5f2550671e235f796f2e1d12b9eaacc92bda42d7b9d89e7c5d
• Download URL:
  https://stacks.cdc.gov/view/cdc/217139/cdc_217139_DS1.pdf
• File Type:
  [PDF - 122.15 KB ]