Possible Pro-Carcinogenic Effect of Endotoxin on Lung Cancer in an Extended Follow-Up of Shanghai Women Textile Workers

Details

• Personal Author:
  Applebaum K ; Astrakianakis G ; Checkoway, Harvey ; Costello S ; Eisen E ; Gao DL ; Li W ; Lundin J ; Ray R ; Seixas, Noah S. ; Thomas D
• Description:
  Objectives: To examine further the association between endotoxin and risk of lung cancer among Shanghai women textile workers in an extended follow-up of the cohort. The initial follow-up indicated an inverse exposure-response relation. Method: We updated a case-cohort study nested within a cohort of 267 400 women. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989-2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. Endotoxin exposures were based on a quantitative job/exposure matrix. Relative risks (hazard ratios [HR]) associated with cumulative exposure, adjusted for age and smoking history, were estimated by Cox proportional hazards modelling adapted for the case-cohort design. We conducted exposure-response trend analyses for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of <15 and >15 years since first exposure. Results: Overall, we observed no associations between cumulative exposure and lung cancer. In contrast, analyses by exposure time windows revealed a modestly elevated risk at the highest 3 exposure quintiles for exposures that occurred >15 years since first exposure; HR=1.28 (95% CI 0.90-1.82), HR=1.27 (95% CI 0.93-1.73), and HR=1.27 (95% CI 0.91-1.77), respectively; p-trend = 0.13. Conclusions: Exposures to endotoxin with long-term, relatively intense exposures were at most weakly associated with lung cancer risk in this cohort. The findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Endotoxins Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Textile Industry Women

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• Keywords:
  Cohort Studies Lung Cancer Risk Factors Textile Workers
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; District of Columbia ; Illinois ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  71
• NIOSHTIC Number:
  nn:20056179
• Citation:
  Occup Environ Med 2014 Jun; 71(Suppl 1):A42-A43
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Occupational and Environmental Medicine. Challenges for Occupational Epidemiology in the 21st Century, EPICOH 2014, June 24-27, 2014, Chicago, Illinois
• Supplement:
  1
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:aaee26fd0f7862c28e59c2a040c7f63f6339e974ae588457576b635e4f58c39106a13b7af472418e74bf29c06549f671703c0d692f8cc482e79155f333d144f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/213835/cdc_213835_DS1.pdf
• File Type:
  [PDF - 69.52 KB ]