Simple, distance-based measurement for paper analytical devices

Details

• Personal Author:
  Cate DM ; Cunningham JC ; Dungchai W ; Henry CS ; Volckens J
• Description:
  Paper-based analytical devices (PADs) represent a growing class of elegant, yet inexpensive chemical sensor technologies designed for point-of-use applications. Most PADs, however, still utilize some form of instrumentation such as a camera for quantitative detection. We describe here a simple technique to render PAD measurements more quantitative and straightforward using the distance of colour development as a detection motif. The so-called distance-based detection enables PAD chemistries that are more portable and less resource intensive compared to classical approaches that rely on the use of peripheral equipment for quantitative measurement. We demonstrate the utility and broad applicability of this technique with measurements of glucose, nickel, and glutathione using three different detection chemistries: enzymatic reactions, metal complexation, and nanoparticle aggregation, respectively. The results show excellent quantitative agreement with certified standards in complex sample matrices. This work provides the first demonstration of distance-based PAD detection with broad application as a class of new, inexpensive sensor technologies designed for point-of-use applications. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Enzymes Hematologic Tests Metals Nickel Occupational Health Safety
• Keywords:
  Analytical-instruments Analytical-processes Blood-analysis Enzymatic-effects Metabolism Metal-compounds Metallic-compounds Nanotechnology Nickel-compounds Oximes Peroxidases

  More +
• ISSN:
  1473-0197
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  12
• NIOSHTIC Number:
  nn:20043529
• Citation:
  Lab Chip 2013 Jun; 13(12):2397-2404
• Contact Point Address:
  Charles S. Henry, Department of Chemistry, Colorado State University, Fort Collins, CO 80523
• Email:
  chuck.henry@colostate.edu
• CAS Registry Number:
  Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  2013
• Performing Organization:
  Colorado State University - Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20110701
• Source Full Name:
  Lab on a Chip
• End Date:
  20130630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a9a2fd5385dc013974a94f9f4ab31d2b4a1dd8caec9338a3b76bb03071ce137defe9c820171e60d7b852813f7c44324237a296f648fbede636f8dddd5c33deb9
• Download URL:
  https://stacks.cdc.gov/view/cdc/195408/cdc_195408_DS1.pdf
• File Type:
  [PDF - 709.82 KB ]