Attempts to induce sensitization in guinea pigs with nickel complexes.

Details

• Personal Author:
  Katz SA ; Lewis JE ; Samitz MH ; Scheiner DM
• Description:
  Sensitization in guinea-pigs is achieved with a nickel alanine conjugate but not with nickel-sulfate (7786814), nickel-alanine, other nickel-amino-acid complexes or with a complex of nickel (7440020) with soluble guinea-pig skin extract. Nickel-amino-acid complexes and nickel guinea-pig skin complex are thus considered not to be antigenic in guinea-pigs with the technique used. Hypothesis for the apparent failure to induce sensitization are proposed. [Description provided by NIOSH]
• Subjects:
  Antigens Hypersensitivity Metals Metals, Heavy Nickel Occupational Health Safety
• Keywords:
  Alanines Allergies Heavy-metals Nickel-compounds NIOSH-Grant NIOSH-Publication Organo-metallic-compounds Organo-nickel-compounds
• ISSN:
  0001-5555
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  475-480
• Volume:
  55
• Issue:
  6
• NIOSHTIC Number:
  nn:00053948
• Citation:
  Acta Derm Venereol 1975 Oct; 55(6):475-480
• Contact Point Address:
  Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
• CAS Registry Number:
  Nickel (CAS RN 7440-02-0) ; Nickel sulfate (NiSO4) (CAS RN 7786-81-4)
• Federal Fiscal Year:
  1976
• Performing Organization:
  University of Pennsylvania, Philadelphia, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19701201
• Source Full Name:
  Acta Dermato-Venereologica
• End Date:
  19751130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b189152c77881efe622fd77473420dbc3e7b87900da1d301b8e957db566c7437e11fb3d923d263dab498d85f11e0c7ee7450e96b294e870d8ed10d7f1f85ae10
• Download URL:
  https://stacks.cdc.gov/view/cdc/184088/cdc_184088_DS1.pdf
• File Type:
  [PDF - 797.91 KB ]