Polycyclic aromatic hydrocarbon biomarkers and serum markers of inflammation. A positive association that is more evident in men

Details

• Personal Author:
  Alshaarawy O ; Andrew, Michael E. ; Conway B ; Ducatman A ; Zhu MT
• Description:
  Background: Polycyclic aromatic hydrocarbons (PAHs) are potent atmospheric pollutants, occurring from anthropogenic and natural sources. Several animal studies have reported a positive association of PAHs with inflammation. However, it is not clear if lower background exposure to PAHs is associated with inflammation in humans, independent of smoking, a major source of PAHs. Methods: We examined participants from the National Health and Nutrition Examination Survey 2001-2002, 2003-2004, and 2005-2006. Our exposures of interest were eight urinary monohydroxy polycyclic aromatic hydrocarbon biomarkers. Our outcomes were serum markers of inflammation; C-reactive protein (CRP) (<= 10 mg/L) and total white blood cell (WBC) count (4000-12,000 cells/micro L). Results: Compared to participants with summed biomarkers of low-molecular weight (LMW) PAHs in the lowest quartile, the multivariable odds ratios (95% confidence interval) of high serum CRP (>= 3 mg/L) and high total WBC count (defined as at or above the 95 percentile of total WBC distribution) among participants in the highest exposure quartile were 1.77 (1.13, 2.76) and 1.34 (1.12, 1.60) respectively. Urinary 1-hydroxypyrene, the biomarker of the higher molecular weight pyrene, was positively associated with total WBC count, and to lesser extent with serum CRP. In subsequent analyses, the positive association between LMW PAHs and serum CRP and total WBC count was found to be present within the stratified subgroups, independent of smoking and other potential confounders. The positive association was more evident among adult males when compared to females. Conclusions: Urinary PAH biomarkers were found to be positively associated with serum CRP and total WBC count independent of smoking and other potential confounders. The association was more evident in men. [Description provided by NIOSH]
• Subjects:
  Biomarkers Blood Hydrocarbons Immune System Men Occupational Health Polycyclic Aromatic Hydrocarbons Pyrenes Safety Smokers Surveys And Questionnaires

  More +
• Keywords:
  Author Keywords: Polycyclic Aromatic Hydrocarbons Blood-cells Blood-serum Health-surveys Humans Hydroxy-compounds Immune-reaction Immune-system Inflammation Information-retrieval-systems Molecular-structure NHANES Polycyclic-aromatic-hydrocarbons Proteins Serological-techniques Serology Serum C-reactive Protein Smoking Total White Blood Cell Count

  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  98-104
• Volume:
  126
• NIOSHTIC Number:
  nn:20043408
• Citation:
  Environ Res 2013 Oct; 126:98-104
• Contact Point Address:
  Omayma Alshaarawy, Department of Epidemiology, West Virginia University School of Public Health, Robert C. Byrd Health Sciences Center, 1 Medical Center Drive, PO Box 9190, Morgantown, WV 26505-9190, USA
• Email:
  oalshaarawy@mix.wvu.edu
• CAS Registry Number:
  1-Hydroxypyrene (CAS RN 5315-79-7) ; Pyrene (CAS RN 129-00-0)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e6e09e860626aa34ce03b9f97e7f788df86a8817cfe5f0cc0a96e97ecaac87b2953cf560ee1fabd0134d81ef76199c677607125f76ff86ebe03dfb7ae97e3e63
• Download URL:
  https://stacks.cdc.gov/view/cdc/195304/cdc_195304_DS1.pdf
• File Type:
  [PDF - 276.20 KB ]