Sensitive Biomarker of Polycyclic Aromatic Hydrocarbons (PAHs): Urinary 1-Hydroxyprene Glucuronide in Relation to Smoking and Low Ambient Levels of Exposure

Details

• Personal Author:
  Cohen B ; Desai M ; Fu J ; Hu Y ; Huang X ; Li X ; Melikian AA ; Nan P ; Qu Q ; Roy N ; Sun J ; Tang MS ; Xue X ; Zhou Z
• Description:
  The study was conducted in a Chinese population with occupational or environmental exposures to polycyclic aromatic hydrocarbons (PAHs). A total of 106 subjects were recruited from coke-oven workers (workers), residents in a metropolitan area (residents) and suburban gardeners (gardeners). All subjects were monitored twice for their personal exposures to PAHs. The biological samples were collected for measurements of 1-hydroxypyrene (1-OHP) and cotinine in urine. The geometric means of personal exposure levels of pyrene, benz(a)anthracene (BaA) and benzo(a)pyrene (BaP) in workers were 1.470, 0.978 and 0.805 microg m-3, respectively. The corresponding levels in residents were 0.050, 0.034 and 0.025 microg m-3; and those in gardeners were 0.011, 0.020 and 0.008 microg m-3, respectively. The conjugate of 1-OHP with glucuronide (1-OHP-G) is the predominant form of pyrene metabolite in urine and it showed strong associations with exposures not only to pyrene, but also to BaA, BaP and total PAHs. Most importantly, a significant difference in 1-OHP-G was even detected between the subgroups with exposures to BaP at < 0.010 and > 0.010 but < 0.020 microg m-3, suggesting that 1-OHP-G is a good marker that can be used for the risk assessment of BaP exposure at levels currently encountered in ambient air. Furthermore, multiple regression analyses of 1-OHP-G on PAHs exposure indicated that cigarette smoke was a major confounding factor and should be considered and adjusted for while using 1-OHP to estimate PAHs exposure. [Description provided by NIOSH]
• Subjects:
  Biomarkers Environmental Exposure Environmental Monitoring Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Pyrenes Risk Assessment Risk Factors Safety Smokers Urine

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• Keywords:
  Biological-effects Biological-monitoring Environmental-exposure Exposure-assessment Exposure-levels Humans Occupational-exposure Pollutants Pollution Polycyclic-aromatic-hydrocarbons Risk-analysis Risk-factors Smoking Ultrasonic-testing Urinalysis

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  306-318
• Volume:
  11
• Issue:
  4
• NIOSHTIC Number:
  nn:20031376
• Citation:
  Biomarkers 2006 Jul-Aug; 11(4):306-318
• CAS Registry Number:
  Benzanthracene (CAS RN 56-55-3) ; Benzo[a]pyrene (CAS RN 50-32-8) ; Pyrene (CAS RN 129-00-0)
• Federal Fiscal Year:
  2006
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20020101
• Source Full Name:
  Biomarkers
• End Date:
  20041231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fc55a472064b6575fe2460273db0e5c4872ec1c7dc33a6331a4985734c5df5a8629943d27c3a75bd2b6d282780c93ed74bcec708abf330c24a14af01c7c0e0b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/191636/cdc_191636_DS1.pdf
• File Type:
  [PDF - 392.75 KB ]