Is bisphenol-A exposure during pregnancy associated with blood glucose levels or diagnosis of gestational diabetes

Details

• Personal Author:
  Carabin H ; Cowan L ; Goodman JR ; Koch HM ; Peck JD ; Robledo C ; Stoner JA
• Description:
  Recent epidemiological studies indicate bisphenol A (BPA), an estrogenic chemical used in production of epoxy, polycarbonate, and plastic may increase risk of insulin resistance and type 2 diabetes. Exposure to BPA during pregnancy may contribute to development of gestational diabetes mellitus (GDM), a precursor to type 2 diabetes in women. This pilot study examined the association between BPA exposure, fasting blood glucose levels (FBG), and GDM diagnosis during pregnancy. Banked urine samples from 22 cases of GDM and 72 controls were analyzed for total (free BPA + conjugates) urinary BPA concentrations (µg/L). FBG levels (mg/dl) were obtained from 1-h 50-g glucose tolerance tests (GTT) that women underwent for routine GDM screening (mean gestational age = 26.6 weeks, SD = 3.8). Those with an initial screening value = 135 mg/dl underwent 3-h 100 g oral GTT. GDM diagnoses were made when the initial screening value was = 200 mg/dl or when values at = 2 time points exceeded 3-h oral GTT thresholds. Among controls, median FBG levels (mg/dL) did not differ across exposure tertiles, defined according to the distribution of total specific-gravity-adjusted urinary BPA concentrations. Logistic regression models controlling for race/ethnicity did not provide evidence of association between BPA exposure and case status across increasing tertiles of BPA exposure (number of GDM cases/controls in tertile1: 13/24; in tertile 2: 6/24; in tertile 3: 3/24). Findings do not support a relationship between total urinary BPA concentrations and altered glucose metabolism during pregnancy. However, due to study limitations, findings need to be interpreted with caution. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Chemistry Epidemiology Epoxy Resins Hazardous Substances Hematologic Diseases Men Occupational Health Phenol Pregnancy Risk Assessment Risk Factors Safety Urine Women

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• Keywords:
  Air-contamination Analytical-processes Blood-disorders Chemical-composition Chemical-properties Diseases Epoxy-compounds Exposure-levels Humans Models Phenols Risk-factors Toxins Urinalysis

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• ISSN:
  1528-7394
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Maryland ; Oklahoma ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  76
• Issue:
  4
• NIOSHTIC Number:
  nn:20043366
• Citation:
  J Toxicol Environ Health A 2013 Oct; 76(4):865-873
• Contact Point Address:
  Candace Robledo, PhD, MPH, at her current address, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd, Room 7B
• Email:
  robledoc@mail.nih.gov
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7) ; Phenol (CAS RN 108-95-2)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:28d472218de9a9a9398592fc3d134381155697a5aec8c1eecddc64a17e70ec3b4ef02ae21aa34aee7e773371608d40961b63422e6aeae2bb73729ebfc8acd746
• Download URL:
  https://stacks.cdc.gov/view/cdc/195283/cdc_195283_DS1.pdf
• File Type:
  [PDF - 315.15 KB ]