A Possible Approach to Improving the Reproducibility of Urinary Concentrations of Phthalate Metabolites and Phenols During Pregnancy

Details

• Personal Author:
  Aguiar A ; Calafat, Antonia M. ; Coull BA ; Gardiner JC ; Korrick SA ; Schantz SL ; Xiaoyun Ye ; Yazdy MM
• Description:
  In epidemiologic studies, classifying episodic exposures to chemicals with short half-lives, such as phthalates and phenols, is challenging. We assessed whether accounting for sources of variability unrelated to exposure pathways would improve the reproducibility of urine concentrations of select phthalate metabolites and phenols. In 2011, a subset of pregnant women (n = 19) enrolled in a prospective study provided first morning urine samples every 3-4 weeks between 16 and 36 weeks gestation. At the time of collection, we identified potential contributors to variations in urinary concentrations: weight gain, gestational age, time slept, time since awoke, time since last food/drink, and time since last void. We estimated intraclass correlation coefficients (ICCs) among repeat urine concentrations with and without adjustment for sources of variability using a random intercept linear mixed model. Concentrations of monoethyl phthalate, butyl, and propyl parabens were the most reproducible (ICCs: 0.68, 0.56, and 0.56, respectively). However, adjustment for potential sources of variability unrelated to exposure pathways did not materially improve reproducibility nor the ability of a single sample to predict exposure based on average biomarker concentrations across pregnancy. Future studies should carefully consider the exposure timeframe and the reliability of using biomarker concentrations from a single time point to represent exposures over pregnancy. [Description provided by NIOSH]
• Subjects:
  Biomarkers Body Weight Chemistry Diet Endocrine System Environmental Exposure Epidemiology Occupational Health Phenol Phthalic Acids Pregnancy Risk Assessment Risk Factors Safety Sleep Surveys And Questionnaires Urine Women

  More +
• Keywords:
  Author Keywords: Child Exposure/Health Body Weight Chemical Composition Chemical Properties Endocrine Disruptors Environmental Exposure Exposure Levels Humans Monitoring Systems Phenols Phthalates Prenatal Exposure Questionnaires Risk Factors Urinalysis

  More +
• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Illinois ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  448-460
• Volume:
  28
• Issue:
  5
• NIOSHTIC Number:
  nn:20055409
• Citation:
  J Expo Sci Environ Epidemiol 2018 Sep; 28(5):448-460
• Contact Point Address:
  Susan Korrick, M.D., M.P.H., Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115
• Email:
  susan.korrick@channing.harvard.edu
• CAS Registry Number:
  Monoethyl phthalate (CAS RN 2306-33-4) ; Phenol (CAS RN 108-95-2)
• Federal Fiscal Year:
  2018
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:929fce3ef478a4582e8e240faae5ff3a156142841c1a1857f9ed86d53d344ffe3697cb21fa56704a855efca4d1d835b8b8a83882a60b2e152bd292e88edaa7bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/213270/cdc_213270_DS1.pdf
• File Type:
  [PDF - 488.38 KB ]