Biodiesel versus diesel exposure: enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

Details

• Personal Author:
  Birch, M. Eileen ; Bugarski, Aleksandar D. ; Farcas MT ; Gutkin DW ; Hatfield MK ; Hummer JA ; Kagan VE ; Kisin E ; Schwegler-Berry D ; Shurin MR ; Shvedova AA ; Yanamala N
• Description:
  The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable approach to reduce occupational and environmental exposures to particulate matter (PM). Due to its lower particulate mass emissions compared to D, use of BD is thought to alleviate adverse health effects. Considering BD fuel is mainly composed of unsaturated fatty acids, we hypothesize that BD exhaust particles could induce pronounced adverse outcomes, due to their ability to readily oxidize. The main objective of this study was to compare the effects of particles generated by engine fueled with neat BD and neat petroleum-based D. Biomarkers of tissue damage and inflammation were significantly elevated in lungs of mice exposed to BD particulates. Additionally, BD particulates caused a significant accumulation of oxidatively modified proteins and an increase in 4-hydroxynonenal. The up-regulation of inflammatory cytokines/chemokines/growth factors was higher in lungs upon BD particulate exposure. Histological evaluation of lung sections indicated presence of lymphocytic infiltrate and impaired clearance with prolonged retention of BD particulate in pigment laden macrophages. Taken together, these results clearly indicate that BD exhaust particles could exert more toxic effects compared to D. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Hazardous Substances Laboratories Lung Occupational Health Oxidants Particulate Matter Petroleum Respiratory System Safety Vehicle Emissions

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• Keywords:
  Author Keywords: Aspiration Exposure Biodiesel Particle Retention Cytokine Panel Diesel-emissions Diesel-engines Diesel-exhausts Health-hazards Inflammation Laboratory-animals Lipid Droplets Oxidative-metabolism Particulates Pulmonary Toxicity

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  373-383
• Volume:
  272
• Issue:
  2
• NIOSHTIC Number:
  nn:20043049
• Citation:
  Toxicol Appl Pharmacol 2013 Oct; 272(2):373-383
• Contact Point Address:
  Anna A. Shvedova , Pathology and Physiology Research Branch (MS-2015), 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  ats1@cdc.gov
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Mining ; Manufacturing ; Public Safety
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3eff9668690ac532882cd57ca01f0c4820276fb1cf914f51e17bcc04879c87e7b766810d323e4617576dba4c44b3c867d4266e67e0499e2ac8bf7d2da71a9059
• Download URL:
  https://stacks.cdc.gov/view/cdc/195071/cdc_195071_DS1.pdf
• File Type:
  [PDF - 1.47 MB ]