Time course of pulmonary responses to inhaled multiwalled carbon nanotubes

Details

• Personal Author:
  Battelli LA ; Castranova, Vincent ; Chen BT ; Endo M ; Frazer D ; Friend S ; Hubbs, Ann F. ; McKinney W ; Mercer RR ; Porter DW ; Scabilloni JF ; Schwegler-Berry D ; Tsuruoka S ; Wolfarth MG ; Wu N
• Description:
  In the present study, an aerosol of multi-walled carbon nanotubes (MWCNT) was produced with an acoustical generator, and airborne concentration and size distribution was determined. Mice were exposed by whole body inhalation to MWCNT (5 mg/m3, 5 hours/day, 12 days) and pulmonary responses were monitored at 1 day, 2, 4, 12, 24 and 48 weeks post-exposure. Pulmonary responses were investigated using whole lung lavage, histopathology, morphometry, and enhanced darkfield light microscopy studies. MWCNT lung burden was also measured to assess MWCNT clearance. Data indicate that the lung burdens of MWCNT in this study represent lung burdens relevant to estimated human occupational exposures and caused time-dependent pulmonary inflammation, damage and pulmonary fibrosis. Using enhanced darkfield microscopy, MWCNT fibers were found in lavage of the pleural space, parietal pleura, and respiratory muscles of the diaphragm and chest wall. The time course of pulmonary responses and their relationship to MWCNT lung burden and clearance will be discussed. [Description provided by NIOSH]
• Subjects:
  Aerosols Environmental Monitoring Laboratories Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Toxicology

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• Keywords:
  Dose-response Exposure-assessment Exposure-levels Fiber-deposition Histopathology Inhalation-studies Laboratory-animals Laboratory-techniques Lung-burden Lung-fibrosis Lung-function Lung-irritants Microscopy Nanotechnology Pleural-cavity Pulmonary-disorders Pulmonary-function Pulmonary-system

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; OSHA Region 6 ; Texas ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  4
• Volume:
  132
• Issue:
  1
• NIOSHTIC Number:
  nn:20042370
• Citation:
  Toxicologist 2013 Mar; 132(1):4
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d14d7d2e01df44acfacce34139d9fc9d55205801ce025cee40c3d570b8d9b3d9c284f59b3c234ac13c0457d689eed03364679cb5f3c4369fef68c053d1af3774
• Download URL:
  https://stacks.cdc.gov/view/cdc/194605/cdc_194605_DS1.pdf
• File Type:
  [PDF - 568.63 KB ]