Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women

Details

• Personal Author:
  Baker, Dean B. ; Fuller JM ; Kesner JS ; Krieg EF Jr. ; Luderer U ; Meadows JW ; Tramma SL ; Yang H
• Description:
  BACKGROUND: For 15 months in 1981-1982, the commercial milk supply on the Hawaiian island of Oahu was contaminated with heptachlor epoxide, a metabolite of the insecticide heptachlor, resulting in gestational and/or lactational exposure to offspring of women who drank cow milk during that period. Objective: To determine whether gestational and lactational exposure to heptachlor epoxide alters reproductive function and age at puberty in men or women. Methods: 457 participants were recruited from a prior high school enrollment sampling frame of 20,000 adults born during 1981-1982 who lived on Oahu since at least first grade. Number of glasses of cow milk consumed weekly by the mother during the participant's gestation was used as a surrogate measure of heptachlor epoxide exposure. Reproductive function measures included semen analyses; reproductive hormones or their metabolites in daily urine specimens for one menstrual cycle; serum reproductive hormone levels in both sexes; and reported ages of onset for pubertal milestones. RESULTS: We observed no strong associations of heptachlor epoxide exposure during gestation and lactation with reproductive endpoints. In females, heptachlor epoxide exposure was associated with longer luteal phase length and slower drop in the ratio of estradiol to progesterone metabolites after ovulation. In males, heptachlor epoxide exposure was weakly associated with higher serum follicle stimulating hormone and luteinizing hormone concentrations, but no dose-response relationship was apparent. CONCLUSIONS: The results provide limited evidence that gestational and lactational exposure to heptachlor epoxide, due to milk contamination on Oahu in 1981-1982, resulted in clinically significant disturbances of reproductive function in men or women. [Description provided by NIOSH]
• Subjects:
  Aging Endocrine System Energy Metabolism Insecticides Men Occupational Health Safety Urogenital System Women
• Keywords:
  Age-groups Author Keywords: Heptachlor Children Contaminated-food Exposure-levels Hormone-activity Hormones Humans In-utero-exposure Lactation Menstrual Cycle Metabolites Organochlorine Prenatal-exposure Puberty Reproduction Reproductive-effects Reproductive-system Semen Analysis Statistical-analysis

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  84-94
• Volume:
  121
• NIOSHTIC Number:
  nn:20042336
• Citation:
  Environ Res 2013 Feb; 121:84-94
• Contact Point Address:
  Ulrike Luderer, Center for Occupational and Environmental Health and Division of Occupational and Environmental Medicine, Depaartment of Medicine, Universitiy of California Irvine, 100 Theory, Suite 100, Irvine, CA 92617
• Email:
  uluderer@uci.edu
• CAS Registry Number:
  Heptachlor (CAS RN 76-44-8)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cf107e4e6fcb51b361c735a6edebae89fdaca7166613d240071ae11bd26a0445fd8e512de971a16d8c82a97a14cdd9937ff1ad7895c3df85c6fb370f3ce351d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/194588/cdc_194588_DS1.pdf
• File Type:
  [PDF - 177.27 KB ]