Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells

Details

• Personal Author:
  Castranova, Vincent ; Fadeel B ; Kagan VE ; Khaliullin T ; Kisin ER ; Kotchey GP ; Mathur S ; Murray AR ; Pareso S ; Shurin GV ; Shurin MR ; Shvedova AA ; Stanley S ; Star A ; Tkach AV ; Yanamala N
• Description:
  Graphene oxide (GO) and C(60) - or C(60) -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells.T-cells in different ways. While C(60) -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C(60) -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines. [Description provided by NIOSH]
• Subjects:
  Antigens Cytology Immune System Occupational Health Safety
• Keywords:
  Author Keywords: Antigens Cell-alteration Cell-function Cellular-reactions Dendritic Cells Dose-response Fullerenes Graphene Oxide Immune-reaction Immune-system Immune-system-disorders Immune Suppression Oxides Proteins Vaccines

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• ISSN:
  1613-6810
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  9
• NIOSHTIC Number:
  nn:20041340
• Citation:
  Small 2013 May; 9(9-10):1686-1690
• Contact Point Address:
  Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown WV 26505, USA
• Email:
  ats1@cdc.gov
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Small
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:83046495a44877ef63babf4830550eee5f2acb1396aa5d39a8ab27b70734b4ff45ae05990bba4ee9b05d2170a7a9ed59e3b98ed5459e891b5f45d14b4b6d9d7c
• Download URL:
  https://stacks.cdc.gov/view/cdc/193937/cdc_193937_DS1.pdf
• File Type:
  [PDF - 771.86 KB ]