Comparison and evaluation of urinary biomarkers for occupational exposure to spray adhesives containing 1-bromopropane

Details

• Personal Author:
  B'Hymer, Clayton ; Cheever KL ; Hanley, Kevin W. ; Johnson BC ; Marlow, Kate L. ; Mathias PI
• Description:
  Three metabolites of 1-bromopropane (1-BP) were measured in urine samples collected from 30 workers exposed to 1-BP at two facilities making furniture seat cushions and evaluated for use as biomarkers of exposure. The mercapturic acid metabolite,N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys), 3-bromopropionic acid (3-BPA), and bromide ion levels (Br-) were quantitated for this evaluation. The high exposure group consisted of 13 workers employed as adhesive sprayers who assembled foam cushions using 1-BP containing spray adhesives and the low exposure group consisted of 17 non-sprayers, who worked in various jobs without spraying adhesives. All workers' urine voids were collected over the same 48 hour period at work, and at home before bedtime, and upon awakening. Urinary AcPrCys and Br-levels were elevated in the sprayers compared to that of non-sprayers. Following HPLC-MS/MS analysis of mercapturic acid metabolite levels, 50 urine samples having the highest levels of AcPrCys were analyzed for 3- BPA. No 3-BPA was detected in any of the samples. The data collected from this study demonstrate that ACPrCys and Br- are effective biomarkers of 1-BP exposure, but 3-BPA is not. [Description provided by NIOSH]
• Subjects:
  Adhesives Biomarkers Bromides Men Occupational Health Propane Safety Urine Women Workplace
• Keywords:
  Author Keywords: 1-bromopropane Biomarker Exposure Exposure-levels Humans Propanes Sprays Urinalysis Work-environment Workers
• ISSN:
  1537-6516
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  7
• NIOSHTIC Number:
  nn:20040753
• Citation:
  Toxicol Mech Methods 2012 Sep; 22(7):526-532
• Contact Point Address:
  Patricia I Mathias MS, NIOSH, DART, Taft Laboratories, 4676 Columbia Parkway, Cincinnati, 45226
• Email:
  pmathias@cdc.gov
• CAS Registry Number:
  3-Bromopropionic acid (CAS RN 590-92-1)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology Mechanisms and Methods
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:808b2bc173cf8001dab65c64c3c19a71b7ee471b48778889e8f8b5e967049e2c09de44646dc6d62e12e353dd29b6e58424b6f1566df2bb8e434605a01b073d6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/193507/cdc_193507_DS1.pdf
• File Type:
  [PDF - 669.13 KB ]