Hazard and risk assessment of workplace exposure to engineered nanoparticles: methods, issues, and carbon nanotube case study

Details

• Personal Author:
  Castranova, Vincent ; Kuempel, Eileen D. ; Castranova, Vincent ; Kuempel, Eileen D.
• Description:
  Toxicology data from experimental studies in animals are frequently used in risk assessment when human dose-response data are not available. Collaborations among industrial hygienists, toxicologists, risk assessors, and other disciplines provide an opportunity to develop an improved scientific data basis for assessing the risk of exposure to nanomaterials. In this chapter, the components of the risk assessment process are described, with focus on occupational risk assessment of inhaled particles. A case study is presented using rat subchronic inhalation data of multiwalled carbon nanotubes (MWCNT) to illustrate the application of risk assessment methods to engineered nanoparticles using currently available data. Issues in using these data in quantitative risk estimation are discussed, as are research needs to reduce the uncertainties in the risk assessment of occupational exposure to nanomaterials. [Description provided by NIOSH]
• Subjects:
  Occupational Health Radiation Dosimeters Risk Assessment Safety
• Keywords:
  Author Keywords: Risk Assessment Paradigm Carbon Nanotubes Dose-response Dose-response Assessment Dosimetry Hazard Assessment Nanotechnology Quantitative-analysis Risk-analysis Temporal Extrapolation
• ISBN:
  9781437778632
• Publisher:
  William Andrew
• Document Type:
  Text
• Genre:
  Book ; Book
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; HELD - Health Effects Laboratory Division ; EID - Education and Information Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  65-97
• NIOSHTIC Number:
  nn:20040220
• Citation:
  Assessing Nanoparticle Risks to Human Health, Micro & Nano Technologies Series. Ramachandran G, ed., Waltham, MA: William Andrew, 2011 Sep; :65-97
• Editor(s):
  Ramachandran G ; Ramachandran G
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Assessing Nanoparticle Risks to Human Health, Micro & Nano Technologies Series
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b53625c7aa892de86568c9154ae6472676d997123335c28203f7172e12de0440a0942dc7b881366e9ba40f858034a1eee07591b79dd5007dd1fe6d7f6943202f
• Download URL:
  https://stacks.cdc.gov/view/cdc/193164/cdc_193164_DS1.pdf
• File Type:
  [PDF - 10.81 MB ]