Mathematical models of skin permeability: an overview

Details

• Personal Author:
  Anissimov YG ; Bunge AL ; Frasch, H. Fredrick ; Guy RH ; Hadgraft J ; Kasting GB ; Lane ME ; Mitragotri S ; Roberts MS
• Description:
  Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure-permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects. [Description provided by NIOSH]
• Subjects:
  Drug Therapy Occupational Health Safety Skin Skin Absorption Women Workplace
• Keywords:
  Author Keywords: Transdermal Drug-therapy Exposure Assessment Mathematical Mathematical-models Model Models Permeability Quantitative-analysis Skin-absorption Statistical-analysis Stratum Corneum Theory Work-environment Workplace-studies

  More +
• ISSN:
  0378-5173
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 8 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  115-129
• Volume:
  418
• Issue:
  1
• NIOSHTIC Number:
  nn:20039915
• Citation:
  Int J Pharm 2011 Oct; 418(1):115-129
• Contact Point Address:
  Samir Mitragotri, Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 USA
• Email:
  samir@engineering.ucsb.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  International Journal of Pharmaceutics
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0e69a88f915d4b432c7d00f7de5d657ab03391068350410a089ef2a8c4336fb5f7605f43accf9ee6e9b8987b72981fecf06653f99963aecc2d7414901cd9380d
• Download URL:
  https://stacks.cdc.gov/view/cdc/192968/cdc_192968_DS1.pdf
• File Type:
  [PDF - 550.98 KB ]