A computer-controlled whole-body inhalation exposure system for the oil dispersant COREXIT EC9500A

Details

• Personal Author:
  Bledsoe T ; Cumpston J ; Frazer D ; Goldsmith WT ; Jackson M ; Law B ; McKinney W ; Siegel P
• Description:
  An automated whole-body inhalation exposure system capable of exposing 12 individually housed rats was designed to examine the potential adverse health effects of the oil dispersant COREXIT EC9500A, used extensively during the Deepwater Horizon oil spill. A computer-controlled syringe pump injected the COREXIT EC9500A into an atomizer where droplets and vapor were formed and mixed with diluent air. The aerosolized COREXIT EC9500A was passed into a customized exposure chamber where a calibrated light-scattering instrument estimated the real-time particle mass concentration of the aerosol in the chamber. Software feedback loops controlled the chamber aerosol concentration and pressure throughout each exposure. The particle size distribution of the dispersant aerosol was measured and shown to have a count median aerodynamic diameter of 285 nm with a geometric standard deviation of 1.7. The total chamber concentration (particulate + vapor) was determined using a modification of the acidified methylene blue spectrophotometric assay for anionic surfactants. Tests were conducted to show the effectiveness of closed loop control of chamber concentration and to verify chamber concentration homogeneity. Five automated 5-h animal exposures were performed that produced controlled and consistent COREXIT EC9500A concentrations (27.1 +/- 2.9 mg/m3, mean +/- SD). [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Animals Chemistry Laboratories Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Aerosol-particles Airborne-particles Animal-studies Chemical Agents Chemical Analysis Exposure-chambers Exposure-methods Hazardous Waste Cleanup Inhalation-studies Laboratory-animals Laboratory-testing Oil Spills

  More +
• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  74
• Issue:
  21
• NIOSHTIC Number:
  nn:20039675
• Citation:
  J Toxicol Environ Health A 2011 Nov; 74(21):1368-1380
• Contact Point Address:
  William Travis Goldsmith, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  Wbg4@cdc.gov
• CAS Registry Number:
  1-(1-Butoxy-2-propoxy)-2-propanol (CAS RN 29911-28-2) ; Distillates (petroleum), hydrotreated light (CAS RN 64742-47-8) ; Polyethylene glycol sorbitan trioleate (CAS RN 9005-70-3) ; Polyoxyethylene sorbitan monooleate (CAS RN 9005-65-6) ; Sodium bis(2-ethylhexyl) sulfosuccinate (CAS RN 577-11-7) ; Sorbitan mono-(9Z)-9-octadecenoate (CAS RN 1338-43-8)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:68c9ee930d939c7761cab0f29ee2efee50866bb7d3adedb4257a2c3e73c4af88ae7250b960d18a52118534fc5436b10fb9a7404bec22839f5a05840e8cfe54ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/192831/cdc_192831_DS1.pdf
• File Type:
  [PDF - 737.30 KB ]