Association of general fatigue with cellular immune indicators among healthy white-collar employees

Details

• Personal Author:
  Irie M ; Nakata A ; Takahashi M
• Description:
  OBJECTIVE: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. METHODS: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). RESULTS: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells (β = -.407) and NKCC (β = -.215), whereas MQ fatigue score was significantly associated with reduced NK cells (β = -.290) but not with NKCC (β = -.127). CONCLUSION: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees. Description provided by NIOSH
• Subjects:
  • Fatigue
  • Immune System
  • Occupational Health
  • Safety
• Keywords:
  • Fatigue
  • Worker-motivation
  • Worker-health
  • Work-performance
  • Immune-system-disorders
  • Immunologic-disorders
  • Immunology
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  53
• Issue:
  9
• NIOSHTIC Number:
  nn:20039438
• Citation:
  J Occup Environ Med 2011 Sep; 53(9):1078-1086
• Contact Point Address:
  Akinori Nakata, PhD, Division of Applied Research Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226
• Email:
  cji5@cdc.gov
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Services
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Download URL:
  https://stacks.cdc.gov/view/cdc/192714/cdc_192714_DS1.pdf
• File Type:
  [PDF - 338.19 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:483d0178518c89a8caff49d57710915aeedc880424c98915d86f660a0f46d11ddec7384f2f95077bfb4153264f1a6eaa26025e444fd132cfd26e215ef3492554