Single-Nucleotide Polymorphisms in Selected Cytokine Genes and Risk of Adult Glioma

Details

• Personal Author:
  Brenner AV ; Butler MA ; Chanock SJ ; Fine HA ; Inskip PD ; Linet MS ; Rothman N ; Ruder, Avima M. ; Schulte, Paul A. ; Wang SS
• Description:
  A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma. [Description provided by NIOSH]
• Subjects:
  Genetics Hypersensitivity Immune System Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Allergens Allergies Autoimmunity Genetic-factors Immune-reaction Immune-system Immune-system-disorders Immunologic-disorders Immunology Risk-analysis Risk-factors

  More +
• ISSN:
  0143-3334
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  10
• NIOSHTIC Number:
  nn:20033033
• Citation:
  Carcinogenesis 2007 Oct; 28(10):2543-2547
• Contact Point Address:
  A.V. Brenner, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238
• Email:
  brennera@mail.nih.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Carcinogenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07a00f73b19554a295538d88cf56c0bbcad3926588793da109c061ee6e1e4ef157a55b3fb9d3e3766b30607a0aea712e30dde90ec6d646735400aa7a7e845502
• Download URL:
  https://stacks.cdc.gov/view/cdc/188764/cdc_188764_DS1.pdf
• File Type:
  [PDF - 104.43 KB ]