Single-Nucleotide Polymorphisms in Selected Cytokine Genes and Risk of Adult Glioma

Details

• Personal Author:
  Brenner AV ; Butler MA ; Chanock SJ ; Fine HA ; Inskip PD ; Linet MS ; Rothman N ; Ruder, Avima M. ; Schulte, Paul A. ; Wang SS
• Description:
  A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma. Description provided by NIOSH
• Subjects:
  • Genetics
  • Hypersensitivity
  • Immune System
  • Occupational Health
  • Risk Assessment
  • Risk Factors
  • Safety
• Keywords:
  • Immune-system-disorders
  • Immunologic-disorders
  • Immunology
  • Immune-system
  • Immune-reaction
  • Risk-analysis
  • Risk-factors
  • Genetic-factors
  • Autoimmunity
  • Allergies
  More +
• ISSN:
  0143-3334
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  10
• NIOSHTIC Number:
  nn:20033033
• Citation:
  Carcinogenesis 2007 Oct; 28(10):2543-2547
• Contact Point Address:
  A.V. Brenner, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238
• Email:
  brennera@mail.nih.gov
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Carcinogenesis
• Download URL:
  https://stacks.cdc.gov/view/cdc/188764/cdc_188764_DS1.pdf
• File Type:
  [PDF - 104.43 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:07a00f73b19554a295538d88cf56c0bbcad3926588793da109c061ee6e1e4ef157a55b3fb9d3e3766b30607a0aea712e30dde90ec6d646735400aa7a7e845502