Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways

Details

• Personal Author:
  Castranova, Vincent ; Chen BT ; Frazer DG ; Knuckles TL ; Leonard HD ; Nurkiewicz TR ; Yi-J
• Description:
  The widespread increase in the production and use of nanomaterials has increased the potential for nanoparticle exposure; however, the biological effects of nanoparticle inhalation are poorly understood. Rats were exposed to nanosized titanium dioxide aerosols (10 mg lung burden); at 24 h post-exposure, the spinotrapezius muscle was prepared for intravital microscopy. Nanoparticle exposure did not alter perivascular nerve stimulation (PVNS)-induced arteriolar constriction under normal conditions; however, adrenergic receptor inhibition revealed a more robust effect. Nanoparticle inhalation reduced arteriolar dilation in response to active hyperaemia (AH). In both PVNS and AH experiments, nitric oxide synthase (NOS) inhibition affected only controls. Whereas cyclooxygenase (COX) inhibition only attenuated AH-induced arteriolar dilation in nanoparticle-exposed animals. This group displayed an enhanced U46619 constriction and attenuated iloprost-induced dilation. Collectively, these studies indicate that nanoparticle exposure reduces microvascular NO bioavailability and alters COX-mediated vasoreactivity. Furthermore, the enhanced adrenergic receptor sensitivity suggests an augmented sympathetic responsiveness. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Environmental Monitoring Inhalation Exposure Laboratories Lung Microbiology Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Safety

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• Keywords:
  Aerosol-particles Airborne-particles Author Keywords: Microvascular Biological-effects Exposure-assessment Inhalants Inhalation-studies Laboratory-animals Laboratory-testing Lung-function Microscopic-analysis Nanotechnology Nitric Oxide Physical-properties Physiological-effects Physiological-measurements Physiological-response Pulmonary-function Pulmonary-system Quantitative-analysis Respiratory-hypersensitivity Sympathetic Nervous System Titanium Dioxide Vasoactive-agents Wholebody Inhalation

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  7
• NIOSHTIC Number:
  nn:20039348
• Citation:
  Nanotoxicology 2012 Nov; 6(7):724-735
• Contact Point Address:
  Timothy R. Nurkiewicz, Department of Physiology & Pharmacology, Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, 1 Medical Center Drive, West Virginia University, Morgantown, WV 26506
• Email:
  tnurkiewicz@hsc.wvu.edu
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9) ; Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3b363e2e4dfb03f4c85d42cfbb3e52d706cad6dcaa7133da57806b8e50133fbd571eebc0d9b7314da1820ce34028e11fb597712e84659fdb0d5935d40094f17
• Download URL:
  https://stacks.cdc.gov/view/cdc/192683/cdc_192683_DS1.pdf
• File Type:
  [PDF - 683.35 KB ]