Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia

Details

• Personal Author:
  Castranova, Vincent ; Chen F ; Chen T-H ; Cumpston JL ; Kan H ; Kashon ML ; Wu Z ; Young S-H
• Description:
  The inhalation of engineered nanoparticles stimulates the development of atherosclerosis and impairs vascular function. However, the cardiac effects of inhaled engineered nanoparticles are unknown. Here, we investigate the effects of ultrafine titanium dioxide (UFTiO2) on the heart, and we define the possible mechanisms underlying the measured effects. Pulmonary exposure of rats to UFTiO2 increased the phosphorylation levels of p38 mitogen-activated protein kinase and cardiac troponin I, but not Akt, in the heart and substance P synthesis in nodose ganglia. Circulatory levels of proinflammatory cytokines, and blood cell counts and differentials were not significantly changed after pulmonary exposure. Separately, the incubation of cardiac myocytes isolated from naïve adult rat hearts in vitro with UFTiO2 did not alter the phosphorylation status of the same cardiac proteins. In conclusion, the inhalation of UFTiO2 enhanced the phosphorylation levels of cardiac proteins. Such responses are likely independent of systemic inflammation, but may involve a lung-neuron-regulated pathway. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cardiovascular System Environmental Monitoring Laboratories Lung Microbiology Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Safety

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• Keywords:
  Airborne-particles Author Keywords: Nanoparticles Biological-effects Cardiovascular-system Cardiovascular Diseases Exposure-assessment Inhalation-studies Inhalation Study Laboratory-animals Laboratory-testing Lung-function Microscopic-analysis Nanotechnology Particle-aerodynamics Particulates Physical-properties Physiological-effects Physiological-measurements Physiological-response Pulmonary-function Pulmonary-system Quantitative-analysis Respiratory-hypersensitivity Titanium Dioxide Vasoactive-agents

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• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  6
• Issue:
  7
• NIOSHTIC Number:
  nn:20039554
• Citation:
  Nanotoxicology 2012 Nov; 6(7):736-745
• Contact Point Address:
  Hong Kan, PPRB/NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  hvn4@cdc.gov
• CAS Registry Number:
  Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7bb0ee7ca5810774ebaf88194ac51f1b9923f047215709c56ba0cbb10520be9f01bcc1304ba1f31898a5940960b6251fb3afc4f7ef1df81299680c6baba30d56
• Download URL:
  https://stacks.cdc.gov/view/cdc/192749/cdc_192749_DS1.pdf
• File Type:
  [PDF - 755.70 KB ]