Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate

Details

• Personal Author:
  Ball LM ; Fent, Kenneth W. ; Flack SL ; Gaines LGT ; Nylander-French LA ; Thomasen JM ; Whittaker SG
• Description:
  We investigated the utility of 1,6-hexamethylene diamine (HDA) hemoglobin adducts as biomarkers of exposure to 1,6-hexamethylene diisocyanate (HDI) monomer. Blood samples from 15 spray painters applying HDI-containing paint were analyzed for hemoglobin HDA (HDA-Hb) and N-acetyl-1,6-hexamethylene diamine (monoacetyl-HDA-Hb) by GC-MS. HDA-Hb was detected in the majority of workers (≤1.2-37ng/g Hb), whereas monoacetyl-HDA-Hb was detected in one worker (0.06 ng/g Hb). The stronger, positive association between HDA-Hb and cumulative HDI exposure (r(2)=0.3, p<.06) than same day exposure (p>/=0.13) indicates long-term elimination kinetics for HDA-Hb adducts. This association demonstrates the suitability of HDA-Hb adducts for further validation as a biomarker of HDI exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Dermatitis Environmental Monitoring Hypersensitivity Inhalation Exposure Irritants Occupational Health Paint Particulate Matter Respiratory Hypersensitivity Respiratory System Safety

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• Keywords:
  1,6-hexamethylene Diisocyanate (HDI) Adduct Airborne-particles Author Keywords: 1,6-hexamethylene Diamine (HDA) Biological-effects Biomarker Chemical-hypersensitivity Exposure-assessment Hemoglobin Inhalants Inhalation-studies Paint-spraying Particle-aerodynamics Particulates Quantitative-analysis Respiratory-hypersensitivity Respiratory-irritants Statistical-analysis

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 4 ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  261-270
• Volume:
  16
• Issue:
  3
• NIOSHTIC Number:
  nn:20039326
• Citation:
  Biomarkers 2011 May; 16(3):261-270
• Contact Point Address:
  Leena A. Nylander-French, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, CB #7431, Rosenau Hall, Chapel Hill, NC 27599-7431
• Email:
  leena_french@unc.edu
• CAS Registry Number:
  Hexamethylene diisocyanate (CAS RN 822-06-0)
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of North Carolina, Chapel Hill, North Carolina
• Peer Reviewed:
  True
• Start Date:
  20030801
• Source Full Name:
  Biomarkers
• End Date:
  20070731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cc1330a03c46d7bcf394a40e77389415c72baa357bc705ac8a909cb83a5d271fcb2bdced5bca84be98f682cbb3aa5a2dd5e6ae9be49788c2236d6b3ec987fbe9
• Download URL:
  https://stacks.cdc.gov/view/cdc/192671/cdc_192671_DS1.pdf
• File Type:
  [PDF - 809.57 KB ]