Association of overtime work with cellular immune markers among healthy daytime white-collar employees

Details

• Personal Author:
  Irie M ; Nakata A ; Takahashi M
• Description:
  Objectives Even though overtime work has been suspected to be a risk factor for ill health, little research has been done to determine the underlying immunological mechanisms. This study investigated the association between overtime work and cellular immunity among Japanese white-collar workers. Methods A total of 306 healthy, full-time, non-shift, daytime employees (165 men and 141 women), aged 22-69 (mean 36) years, provided a blood sample for the measurement of circulating immune [natural killer (NK), B, and T] cells and NK cell cytotoxicity (NKCC) and completed a questionnaire survey including overtime/month. Blood samples were collected between 09.00-11.00 hours during the working days and participants completed the questionnaire within the two weeks prior to the blood sampling. Stepwise linear regression analyses controlling for confounders were carried out to examine the relationship between overtime work and immune markers. Results Overtime work was mainly related to short sleep duration, increased weight, and reduced job satisfaction, and it was more prevalent among men than women and among younger and married employees. Amount of overtime was inversely associated with NK (CD3-CD56+) cell counts (β=-0.145; P =0.032) but was not associated with NKCC, NKCC/NK cell ratio, T or B cells. Conclusions The NK cell is a lymphocyte that possesses killer activity against tumor and virus-infected cells and constitutes a major component of the innate immune system. A decrease of NK cell counts from overtime work suggests a dampened innate immune defense. However, the finding needs to be further validated with a well-designed study using objective overtime measures [Description provided by NIOSH]
• Subjects:
  Demography Epidemiology Immune System Men Occupational Health Safety Surveys And Questionnaires Women
• Keywords:
  Author Keywords: Cellular Immune Marker Demographic-characteristics Employee Humans Immune-system-disorders Immune Marker Immune System Immunologic-disorders Immunology Natural Killer Cell Occupational Health Overtime Overtime Work Questionnaires Statistical-analysis Work Condition

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• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  56-64
• Volume:
  38
• Issue:
  1
• NIOSHTIC Number:
  nn:20039191
• Citation:
  Scand J Work Environ Health 2012 Jan; 38(1):56-64
• Contact Point Address:
  Akinori Nakata, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C24, Cincinnati, OH 45226
• Email:
  cji5@cdc.gov
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Services
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d76643ed130a77c233e742817769879e91bed63e8de9da1a3040c11a2571bad78b4494746d4bc564c9ebe546f90a94de862ac0f571b08e8b942a2c33c8091be9
• Download URL:
  https://stacks.cdc.gov/view/cdc/192630/cdc_192630_DS1.pdf
• File Type:
  [PDF - 264.83 KB ]