Immunoparesis and Monoclonal Gammopathy of Undetermined Significance Are Disassociated in Advanced Age

Details

• Personal Author:
  Annunziata C ; Burris J ; Cherry BM ; Costello, Richard J. ; Engels EA ; Korde N ; Kwok M ; Landgren O ; Manasanch E ; Roschewski MJ ; Zingone A
• Description:
  Immunoparesis and a skewed serum free light chain (FLC) ratio are indicators of immune dysfunction predictive of progression from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM). Previous studies have reported increased prevalence of MGUS by age, but no study has examined the relationship between immunoparesis and abnormal FLC ratios in the elderly. We screened 453 older adults (median age, 80 years; range, 65-96) to characterize the patterns of immunoparesis and abnormal FLC ratio in relation to MGUS. We defined MGUS in 4.4% of the subjects; the prevalence was 12.5% among individuals of >90 years. In MGUS (vs. non-MGUS) cases, immunoparesis and abnormal FLC ratios were detected in 70.0% (vs. 49.0%; P = 0.07) and 50.0% (vs. 12.9%; P = 0.0001), respectively. Based on small numbers, MGUS patients with abnormal FLC ratio were borderline (P = 0.07) more likely to have immunoparesis. Overall, the prevalence of immunoparesis varied in a nonlinear fashion, with lowest frequencies in the youngest and oldest groups. Our observed disassociation between MGUS prevalence and impaired immunoglobulin production suggests that separate mechanisms are involved in the development of MGUS and immunoparesis in advanced age. These findings emphasize the need for molecularly defined methods to characterize myeloma precursor states and better predict progression to MM. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Blood Epidemiology Immune System Men Occupational Health Safety Women
• Keywords:
  Age Factors Age Groups Biological Factors Blood Cells Bone Marrow Cell Alteration Etiology Hematopoietic System Immune System Disorders Immunoglobulins Immunology Mutation Myeloid Tissue Physiopathology

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• ISSN:
  0361-8609
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  89-92
• Volume:
  88
• Issue:
  2
• NIOSHTIC Number:
  nn:20050749
• Citation:
  Am J Hematol 2013 Feb; 88(2):89-92
• Contact Point Address:
  Ola Landgren, Multiple Myeloma Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 10/Room 13N240, Bethesda, MD 20892, USA
• Email:
  landgreo@mail.nih.gov
• Federal Fiscal Year:
  2013
• Performing Organization:
  Albert Einstein College of Medicine, Inc., Bronx, New York
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  American Journal of Hematology
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:79365837d2a092a3e1ac8cbc8c5437719033b4a21afb17f53eb9151db03cf66f09ffcc044ae07c98dab6df99ebe1dbc4285c85b17c3026a5c528f37bee860c3d
• Download URL:
  https://stacks.cdc.gov/view/cdc/210973/cdc_210973_DS1.pdf
• File Type:
  [PDF - 117.76 KB ]