The effect of amosite and chrysotile asbestos on the clearance of TiO2 particles from the lung.

Details

• Personal Author:
  Ferin J ; Leach LJ
• Description:
  Techniques were developed to assess the effects of air pollutants on the alveolar clearance pattern of inert particles deposited in the lungs of laboratory animals. Amosite (12172735) or chrysotile (12001295) asbestos exposures, relatively short in duration (1-3 hours) and high in concentration (about 10 milligrams per cubic meter) depressed the alveolar clearance of titanium-dioxide (1309633)) particles in rats. This effect was not observed when asbestos air concentrations were reduced to about 10 times the Threshold Limit Value, estimated to be 0.1 milligrams per cubic meter. Extending the postexposure observation period and the number of exposures to 11 or 22 a suppressive effect on titanium-dioxide clearance was seen. How important this late effect is can not be determined at this time. However, the effect of high concentrations of amosite or chrysotile at exposures lasting only a short time should be considered with concern. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asbestos Carcinogens Dust Occupational Health Respiratory System Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Air-contaminants Asbestos-dust Exposure-limits Lung-clearance Lung-dust-burden NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders Respiratory-functions Respiratory-mechanics Test-methods Time-dose-relationship

  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  250-254
• Volume:
  12
• Issue:
  2
• NIOSHTIC Number:
  nn:00068052
• Citation:
  Environ Res 1976 Oct; 12(2):250-254
• Contact Point Address:
  Radiation Biology & Biophysics University of Rochester Dept of Radiation Bio & Biophy Rochester, N Y 14620
• CAS Registry Number:
  Amosite asbestos (CAS RN 12172-73-5) ; Chrysotile (CAS RN 12001-29-5) ; Titania (CAS RN Titania (CAS RN 13463-67-7))
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Rochester, Rochester, New York
• Peer Reviewed:
  True
• Start Date:
  19700901
• Source Full Name:
  Environmental Research
• End Date:
  19791130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:43c9bce24f359160932560d46da8045f20757bc67532b0a3fbc859f8f96f61959e137f403c2ca8af24dfd60e81cb86eb6911ad8528a3e96dc113326683202dcb
• Download URL:
  https://stacks.cdc.gov/view/cdc/184135/cdc_184135_DS1.pdf
• File Type:
  [PDF - 349.40 KB ]