Effects of polymorphic variations in tumor necrosis factor alpha and occupational exposure to grain dust on longitudinal decline in pulmonary function

Details

• Personal Author:
  Koehncke N ; McDuffie HH ; Nakagawa K ; Pahwa P
• Description:
  Background: Longitudinal declines in pulmonary function are associated with individuals experiencing occupational exposure to organic dusts in combination with lifestyle factors such as cigarette smoking and with genetic factors, and interactions between these factors. Objective: To investigate the relationship between polymorphism of genes encoding Tumor Necrosis Factor Alpha (TNF-alpha) and longitudinal lung function decline in grain workers exposed to grain dust. Method: Male grain handlers who participated in the Saskatchewan Grain Workers Surveillance Program from 2002 through 2005 provided demographic, occupational, lifestyle, and respiratory symptoms information as well as pulmonary function measurements and DNA for genotyping. Marginal models using the generalized estimating equations approach were fitted by using a SAS PROC GENMOD to predict the annual decline in Forced Expired Volume in one second (FEV1) and Forced Vital Capacity (FVC). Results: Smoking intensity contributed to the decline in FEV1. Among *1/*1 homozygotes and *1/*2 heterozygotes, grain workers with <10 years in the grain industry had significantly lower FEV1 declines compared to those of the other two exposure groups (>10 and < or equal to 20 years, and >20 years in the grain industry). The annual declines in FEV1 for grain workers who were either *1/*1 homozygote or *1/*2 heterozygote and had been in the grain industry for <10 years were lower by comparison to those of grain workers who were *2/*2 genotype and had been in the industry for <10 years. Conclusion: This research demonstrates that years in the grain industry is an effect modifier between TNF-alpha 308 genotype and longitudinal decline in FEV1 in male subjects exposed to grain dust. [Description provided by NIOSH]
• Subjects:
  Demography Dust Environmental Exposure Environmental Monitoring Environmental Pollution Hazardous Substances Irritants Lung Lung Diseases Occupational Health Particulate Matter Race Factors Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smoke Smokers Tobacco Products

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• Keywords:
  Author Keywords: Grain Dust Demographic-characteristics Dust-exposure Dust-inhalation Dust-particles Environmental-exposure Environmental-hazards Environmental-health-monitoring Environmental-pollution Grain-dusts Health-hazards Longitudinal Decline Lung-disorders Lung-irritants Organic-dusts Particle-aerodynamics Particulates Pulmonary-system Pulmonary-system-disorders Pulmonary Function Quantitative-analysis Racial-factors Respiratory-hypersensitivity Respiratory-infections Respiratory-irritants Respiratory-system-disorders Risk-factors Smoking Statistical-analysis TNF-alpha Tobacco Tobacco-smoke

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• ISSN:
  1059-924X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 5 ; OSHA Region 9 ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  215-221
• Volume:
  14
• Issue:
  2
• NIOSHTIC Number:
  nn:20038816
• Citation:
  J Agromedicine 2009 Apr; 14(2):215-221
• Contact Point Address:
  Punam Pahwa, PhD, Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada
• Email:
  pup165@mail.usask.ca
• Federal Fiscal Year:
  2009
• Performing Organization:
  Marshfield Clinic
• Peer Reviewed:
  True
• Start Date:
  20080901
• Source Full Name:
  Journal of Agromedicine
• End Date:
  20090831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b32ea02a8c97cc0c34896abff6ab989489c0d18fe6753c1140e16d8c92ba359b7fb925fc82bc37214c9b7de99f5397d60f6c4cfeb61f51b66f8c27b64512712
• Download URL:
  https://stacks.cdc.gov/view/cdc/192383/cdc_192383_DS1.pdf
• File Type:
  [PDF - 213.40 KB ]