Risk Factors for Symptom Onset in PI*Z Alpha-1 Antitrypsin Deficiency

Details

• Personal Author:
  Mayer AS ; Newman, Lee S. ; Ruttenber AJ ; Sandhaus RA ; Stoller JK ; Strand M ; Vedal S
• Description:
  BACKGROUND: In an early study of highly symptomatic patients with PI*Z alpha-1 antitrypsin deficiency (AAT), tobacco smoking was identified as a risk factor by comparing the age of symptom onset in smokers and nonsmokers. Age of symptom onset has not been well studied in relationship to other environmental exposures. METHODS: Environmental exposures were assessed in 313 PI*Z adults through retrospective self-administered questionnaire. Age of onset of symptoms with and without these exposures were analyzed through survival analysis. RESULTS: Personal smoking was the most important risk factor, associated with earlier onset of cough and wheeze, and showed a dose-dependent relationship with the onset of dyspnea. Childhood environmental tobacco smoke (ETS) exposure was independently associated with younger age of onset of cough. Earlier onset of wheeze was also associated with childhood respiratory infections and family history of emphysema. The report of childhood respiratory infections was associated with childhood ETS exposure, but no statistically significant interactions were noted. CONCLUSIONS: We conclude that both personal and secondhand exposure to tobacco smoke in childhood are likely to accelerate the onset of symptoms in AAT deficient patients. Respiratory infections in childhood may also contribute to this risk. [Description provided by NIOSH]
• Subjects:
  Age Factors Environmental Exposure Environmental Health Environmental Pollution Irritants Lung Lung Diseases Occupational Health Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smoke Smokers Surveys And Questionnaires Tobacco Products

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• Keywords:
  Age-factors Breathing Environmental-exposure Environmental-factors Environmental-hazards Pulmonary-disorders Pulmonary-function Pulmonary-system-disorders Questionnaires Respiratory-hypersensitivity Respiratory-infections Respiratory-irritants Respiratory-system-disorders Risk-analysis Risk-factors Smoking Statistical-analysis Tobacco-smoke

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• ISSN:
  1176-9106
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  485-492
• Volume:
  1
• Issue:
  4
• NIOSHTIC Number:
  nn:20032906
• Citation:
  Int J Chron Obstruct Pulmon Dis 2006 Dec; 1(4):485-492
• Contact Point Address:
  Annyce S Mayer National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206
• Email:
  mayera@njc.org
• Federal Fiscal Year:
  2007
• Performing Organization:
  National Jewish Medical and Research Center
• Peer Reviewed:
  True
• Start Date:
  20010601
• Source Full Name:
  The International Journal of Chronic Obstructive Pulmonary Disease
• End Date:
  20040531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f44ddbbbf67ddf38cd7644e41c5b6dc4387d904e68f8b027c62f7141de5a9caa6a8f727fc706e56315341dd50ee7e0e2dbd92d2294a6ab4cfd802a67d779c85
• Download URL:
  https://stacks.cdc.gov/view/cdc/186694/cdc_186694_DS1.pdf
• File Type:
  [PDF - 69.38 KB ]