Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice

Details

• Personal Author:
  Antonini JM ; Chen BT ; Erdely A ; Frazer DG ; Hulderman T ; Liston A ; Salmen-Muniz R ; Simeonova PP ; Stone S ; Zeidler-Erdely PC
• Description:
  Epidemiological studies suggest that welding, a process which generates an aerosol of inhalable gases and metal rich particulates, increases the risk for cardiovascular disease. In this study we analyzed systemic inflammation and atherosclerotic lesions following gas metal arc-stainless steel (GMA-SS) welding fume exposure. Apolipoprotein E knockout (apoE-/-) mice, fed a Western diet, were exposed to GMA-SS at 40mg/m3 for 3h/day for ten days (approximately 8.26 mu g daily alveolar deposition). Mice were sacrificed two weeks after exposure and serum chemistry, serum protein profiling and aortic lesion area were determined. There were no significant changes in serum total cholesterol, triglycerides or alanine aminotransferase. Serum levels of uric acid, a potent antioxidant, were decreased perhaps suggesting a reduced capacity to combat systemic oxidative stress. Inflammatory serum proteins interleukin 1 beta (IL-1 beta) and monocyte chemoattractant protein 3 (MCP-3)were increased two weeks after GMA-SS exposure. Analysis of atherosclerotic plaques showed an increase in lesion area as the result of GMA-SS exposure. In conclusion, GMA-SS exposure showed evidence of systemic inflammation and increased plaque progression in apoE-/- mice. These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cardiovascular Diseases Cardiovascular System Laboratories Lung Occupational Health Particulate Matter Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety Welding

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• Keywords:
  Cardiopulmonary-system Cardiopulmonary-system-disorders Cardiovascular-system Cardiovascular-system-disorders Exposure-levels Fumes Gas-welders Inhalation-studies Laboratory-animals Laboratory-testing Lung-tissue Oxidative-processes Particulates Pulmonary-system Pulmonary-system-disorders Quantitative-analysis Respiratory-gas-analysis Respiratory-hypersensitivity Respiratory-system-disorders Welders-lung

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• ISSN:
  0378-4274
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  12-16
• Volume:
  204
• Issue:
  1
• NIOSHTIC Number:
  nn:20038719
• Citation:
  Toxicol Lett 2011 Jul; 204(1):12-16
• Contact Point Address:
  Aaron Erdely, NIOSH/HELD/PPRB, 1095 Willowdale Rd, MS-2015, Morgantown, WV 26505-2888
• Federal Fiscal Year:
  2011
• Peer Reviewed:
  False
• Source Full Name:
  Toxicology Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:047c3f3daf1f6f3a9318172704cf704a2f906784598d122f1619ae5470cc4f2600f395d220ae5b6ef71b48fa691a92e862ee6016ccadc13048de405833f8b665
• Download URL:
  https://stacks.cdc.gov/view/cdc/192332/cdc_192332_DS1.pdf
• File Type:
  [PDF - 243.11 KB ]