Thoracic damping and the relationship between PENH of the thoracic air-flow (IT) and tidal midexpiratory flow (EF50)

Details

• Personal Author:
  Afshari AA ; Frazer DG ; Goldsmith WT ; Jackson MC ; McKinney WG ; Reynolds JS
• Description:
  The thoracic air-flow pattern can be modeled as a response to the action of the respiratory muscles. That response can be viewed as being either under-damped, when IT is initially higher then decays toward the end of exhalation, or damped when IT is initially lower and then rises toward the end of exhalation. Both Penh(IT) and the EF50 tend to decrease as IT damping increases. Previously, it has been reported that the EF50 is reduced when pulmonary conductance, 1/RL, decreases (Glaab et al., Am J Physiol. Lung Cell Mol. Physiol., 2001). In addition, it has been shown that exposure to an inhaled intervention causes an increase in Penh(IBOX) where IBOX represents airflow into and out of a whole body plethysmograph. The increase in Penh(IBOX) results in the Penh(IT) versus RawCG relationship moving upward and to the right (Frazer et al., J. Tox. and Eviron. Health, 2010). Several authors have provided evidence that not all increases in Penh(IBOX) are caused by an increase in RawCG (Bates et al., Am. J. of Respir. Cell and Mol. Biology, 2004). It can be shown theoretically, however, that an increase in damping of the IT waveform following an intervention, in cases where Penh(IBOX) increases, results in a reduction in Penh(IT) and indicates an increase in RawCG (SRAW). A decrease in the EF50 can also be shown to be related to a decrease in IT damping. [Description provided by NIOSH]
• Subjects:
  Cytology Inhalation Exposure Irritants Laboratories Lung Lung Diseases Occupational Health Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Biological-effects Cell-biology Cell-morphology Inhalants Laboratory-testing Lung-irritants Lung-tissue Molecular-biology Pulmonary-disorders Quantitative-analysis Respiratory-hypersensitivity Respiratory-irritants Statistical-analysis Tissue-disorders

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  493-494
• Volume:
  120
• NIOSHTIC Number:
  nn:20038621
• Citation:
  Toxicologist 2011 Mar; 120(Suppl 2):493-494
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Construction ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 50th Annual Meeting and ToxExpo, March 6-10, 2011, Washington, DC
• Supplement:
  2
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b626085cf58954ee4c76176394ab6746986b075c3745f234e018c20aaa3fefa88c28e1d9dc7b461d62ba8da97dfed37da7a54d65526f28a54e46ff296ebff9cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/192269/cdc_192269_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]