Urine bisphenol-A (BPA) level in relation to semen quality

Details

• Personal Author:
  Ferber J ; Gao E ; He Y ; Herrinton LJ ; Li D-K ; Miao M ; Wang J ; Yuan W ; Zhou Z
• Description:
  Objective: To determine whether urine bisphenol-A (BPA) levels are associated with lower semen quality. Design Cohort study: Setting Four regions in China where high exposure to BPA in the workplace existed. Patient(s): 218 men with and without BPA exposure in the workplace. Intervention(s): None. Main Outcome Measure(s): Semen parameters. Result(s): After adjustment for potential confounders using linear regression, increasing urine BPA level was statistically significantly associated with [1] decreased sperm concentration, [2] decreased total sperm count, [3] decreased sperm vitality, and [4] decreased sperm motility. Compared with men who did not have detectable urine BPA levels, those with detectable urine BPA had more than three times the risk of lowered sperm concentration and lower sperm vitality, more than four times the risk of lower sperm count, and more than twice the risk of lower sperm motility. The urine BPA level was not associated with semen volume or abnormal sperm morphology. Similar dose-response associations were observed among men with environmental BPA exposure at levels comparable with those in the U.S population. Despite a markedly reduced sample size, the inverse correlation between increased urine BPA levels and decreased sperm concentration and total sperm count remained statistically significant. Conclusion(s): These results provide the first epidemiologic evidence of an adverse effect of BPA on semen quality. [Description provided by NIOSH]
• Subjects:
  Endocrine System Environmental Exposure Epidemiology Men Occupational Health Phenol Plastics Risk Assessment Safety Urine Urogenital Diseases Urogenital System

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• Keywords:
  Author Keywords: Bisphenol A BPA Dose-response Endocrine-function Endocrine Disruptor Environmental-exposure Fertility Male Fertility Phenols Plastic-products Reproductive-effects Reproductive-system-disorders Risk-analysis Semen Quality Sexual-reproduction Urinalysis

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• ISSN:
  0015-0282
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  95
• Issue:
  2
• NIOSHTIC Number:
  nn:20037786
• Citation:
  Fertil Steril 2011 Feb; 95(2):625-630.e4
• Contact Point Address:
  De-Kun Li, M.D., Ph.D., Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2011
• Performing Organization:
  Kaiser Foundation Research Institute
• Peer Reviewed:
  True
• Start Date:
  20030930
• Source Full Name:
  Fertility and Sterility
• End Date:
  20110929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e3d7d8fc8379924c2c60728db1111e3d610702f21a41fafc0fa865e00230d0c22a8f285a1da8ab9689689eab04dca0808159dc771075efcce8946305e69a6f41
• Download URL:
  https://stacks.cdc.gov/view/cdc/191759/cdc_191759_DS1.pdf
• File Type:
  [PDF - 176.91 KB ]