Occupational Exposure to Bisphenol-a (BPA) and the Risk of Self-Reported Male Sexual Dysfunction

Details

• Personal Author:
  Checkoway, Harvey ; Ferber JR ; Gao E ; He Y ; Herrinton LJ ; Li D ; Miao M ; Qing D ; Wang J ; Weng X ; Wu T ; Yuan W ; Zhou Z ; Zhu Q
• Description:
  BACKGROUND: Animal studies have suggested that bisphenol-A (BPA) is a potential human endocrine disrupter; but evidence from human studies is needed. METHODS: We conducted an occupational cohort study to examine the effect of occupational exposure to BPA on the risk of male sexual dysfunction. Current workers from BPA-exposed and control factories were recruited. The exposed workers were exposed to very high BPA levels in their workplace. Male sexual function was ascertained through in-person interviews using a standard male sexual function inventory. RESULTS: BPA-exposed workers had consistently higher risk of male sexual dysfunction across all domains of male sexual function than the unexposed workers. After controlling for matching variables and potential confounders, exposed workers had a significantly increased risk of reduced sexual desire [odds ratios (OR) = 3.9, 95% confidence interval: 1.8-8.6), erectile difficulty (OR = 4.5, 95% CI 2.1-9.8), ejaculation difficulty (OR = 7.1, 95% CI 2.9-17.6), and reduced satisfaction with sex life (OR = 3.9, 95% CI 2.3-6.6). A dose-response relationship was observed with an increasing level of cumulative BPA exposure associated with a higher risk of sexual dysfunction. Furthermore, compared with the unexposed workers, BPA-exposed workers reported significantly higher frequencies of reduced sexual function within 1 year of employment in the BPA-exposed factories. CONCLUSIONS: Our findings provide the first evidence that exposure to BPA in the workplace could have an adverse effect on male sexual dysfunction. [Description provided by NIOSH]
• Subjects:
  Endocrine System Epidemiology Epoxy Resins Men Occupational Exposure Occupational Health Phenol Plastics Polychlorinated Biphenyls Safety Surveys And Questionnaires Urogenital Diseases Urogenital System

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• Keywords:
  Author Keywords: Bisphenol-A Cohort Study Endocrine-function Epoxy-resins Occupational-exposure Occupational Studies Phenols Plastic-products Plastics-industry Polychlorinated-biphenyls Questionnaires Reproductive-system-disorders Sexual-reproduction

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• ISSN:
  0268-1161
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 10 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  2
• NIOSHTIC Number:
  nn:20036067
• Citation:
  Hum Reprod 2010 Feb; 25(2):519-527
• Contact Point Address:
  D. Li, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
• Email:
  dkl@dor.kaiser.org
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2010
• Performing Organization:
  Kaiser Foundation Research Institute
• Peer Reviewed:
  True
• Start Date:
  20030930
• Source Full Name:
  Human Reproduction
• End Date:
  20110929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:06ee1d1db637c7b317fa2c021cb352a70b145b2701aa87e03f91812b1c403f17b354260d9a0da8c22172c2cae7057aa20fe0bb2f4573fb397bf33c6bd9820cdf
• Download URL:
  https://stacks.cdc.gov/view/cdc/187661/cdc_187661_DS1.pdf
• File Type:
  [PDF - 189.20 KB ]