COPD and Occupational Exposures: A Case-Control Study

Details

• Personal Author:
  Breen V ; Buist S ; Doney B ; Graziani M ; Heumann M ; Hnizdo, Eva ; McBurnie MA ; Villnave J ; Vollmer WM ; Weinmann S
• Description:
  Growing evidence suggests that chronic obstructive pulmonary disease (COPD) is causally associated with certain occupations. The authors conducted a case control study among members of Kaiser Permanente Northwest to evaluate the association of COPD with occupational exposures. Subjects included 388 COPD cases aged 45 and over matched on age group, sex, and cigarette smoking history to 356 controls. Occupation and smoking histories were obtained by telephone interview. Industrial hygienists independently rated each job within an individual's history according to its likelihood of exposure to eight occupational hazard categories thought to cause COPD. Odds ratios (ORs) for the presence of each individual exposure hazard category and for aggregate exposure variables were computed using logistic regression, stratifying on smoking status and adjusting for age, sex, and, for smokers, pack years. Among ever-smokers, occupational exposures most strongly associated with COPD were diesel exhaust (OR = 1.7, 95% CI: 1.1, 2.7) and irritant gases and vapors (OR = 1.7, 95% CI: 2, 2.4). Associations with metal dust and mineral dust were suggested. In the small group of never-smokers (42 cases and 58 controls), a similar pattern was evident. Odds ratios for the overall aggregate exposure measure were 1.5 (95% CI: 1.0, 2.2) for ever-smokers and 1.5 (95% CI: 0.61, 3.7) for never-smokers. These population-based findings add to the literature linking occupational exposures to COPD. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Case Reports Demography Occupational Diseases Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Sex Characteristics Smokers Solvents Tobacco Products Vehicle Emissions

  More +
• Keywords:
  Age-factors Age-groups Case-studies Cigarette-smoking Demographic-characteristics Diesel-exhausts Diseases Gases Occupational-diseases Occupational-exposure Pulmonary-system-disorders Sex-factors Smoking Surveillance Vapors

  More +
• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Oregon ; OSHA Region 10 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  163
• Issue:
  11
• NIOSHTIC Number:
  nn:20030781
• Citation:
  Am J Epidemiol 2006 Jun; 163(11)(Suppl):S214
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Epidemiology. Abstracts of the 2nd North American Congress of Epidemiology, June 21-24, 2006, Seattle, Washington
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0d666af72d7bfff15305f4eb79a3176f2ded813a54c2771bab20433337c1db4eaf09f850677ffed932d1ac03a00f1f4d22faf06428d4d86d9763f65e1263acc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/191284/cdc_191284_DS1.pdf
• File Type:
  [PDF - 376.58 KB ]